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Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis

Laboratoire d′Innovation Thérapeutique, Université de Strasbourg, CNRS, UMR 7200, 67000 Strasbourg, France
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Molecules 2020, 25(21), 4976; https://doi.org/10.3390/molecules25214976
Received: 12 October 2020 / Revised: 23 October 2020 / Accepted: 23 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue Recent Advances in Metal-Catalyzed Domino Reactions)
We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center are formed. View Full-Text
Keywords: gold(I)-catalysis; domino reactions; electrocyclization; heterocycles; hetero Diels–Alder; furopyrans gold(I)-catalysis; domino reactions; electrocyclization; heterocycles; hetero Diels–Alder; furopyrans
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MDPI and ACS Style

Ruch, M.; Brach, N.; Galéa, R.; Wagner, P.; Blond, G. Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis. Molecules 2020, 25, 4976. https://doi.org/10.3390/molecules25214976

AMA Style

Ruch M, Brach N, Galéa R, Wagner P, Blond G. Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis. Molecules. 2020; 25(21):4976. https://doi.org/10.3390/molecules25214976

Chicago/Turabian Style

Ruch, Marie, Nicolas Brach, Roméric Galéa, Patrick Wagner, and Gaëlle Blond. 2020. "Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis" Molecules 25, no. 21: 4976. https://doi.org/10.3390/molecules25214976

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