Next Article in Journal
Rational Design of Polyamine-Based Cryogels for Metal Ion Sorption
Next Article in Special Issue
Coriolic Acid (13-(S)-Hydroxy-9Z, 11E-octadecadienoic Acid) from Glasswort (Salicornia herbacea L.) Suppresses Breast Cancer Stem Cell through the Regulation of c-Myc
Previous Article in Journal
Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing
Previous Article in Special Issue
Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells
Article

Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant Peltophorum pterocarpum

1
Department of Pharmacy, College of Pharmacy, Kangwon National University, 1 Gangwondaegakgil Chuncheon-si, Gangwon-do 24341, Korea
2
Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong district, Hanoi 12116, Vietnam
3
Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam
4
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay District, Hanoi 122100, Vietnam
5
University of Science, Vietnam National University Hochiminh City, 227 Nguyen Van Cu street, District 5, Ho Chi Minh City 748000, Vietnam
6
Department of Emergency Medical Technology, College of Health Science, Kangwon National University, 346 Hwangjo-gil, Dogye-up, Samcheok-si, Gangwon-do 25945, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Luisa Tesoriere and Alessandro Attanzio
Molecules 2020, 25(20), 4800; https://doi.org/10.3390/molecules25204800
Received: 25 September 2020 / Revised: 16 October 2020 / Accepted: 16 October 2020 / Published: 19 October 2020
(This article belongs to the Special Issue Cytotoxic Activity of Plant Extracts)
Peltophorum pterocarpum is regarded as one of the most important medicinal plants in the traditional medicine system of Vietnam. However, scientific evidence for the antioxidant effects against lipid peroxidation and the potential effects in cancer of this plant are lacking. In our experiments, 70% ethanolic extracts of P. pterocarpum leaves (LPP) and stem bark (SPP) were evaluated for their low-density lipoprotein (LDL) oxidation and cytotoxic activity against cancer cell lines. Both LPP and SPP inhibited Cu2+-mediated LDL by increasing the lag time of conjugated diene formation and inhibiting the generation of thiobarbituric acid reactive substances (TBARS) in a dose-dependent manner. In cancer cells, LPP and SPP triggered the most potent cytotoxic effects against human leukemia cells, CRF-SBA and HL-60, with half-maximal inhibitory concentration (IC50) values ranging from 118.5 to 157.2 µg/mL. SPP exhibited significant cytotoxicity against MIA PACA2, A549, and KG cell lines with IC50 values of 167.5, 244.1 and 255.0 µg/mL, respectively. Meanwhile, LPP showed cytotoxic activity against KG with an IC50 value of 228.1 µg/mL. SPP mediated cytotoxicity in HL-60 and CCRF-SBA cells through the activation of the apoptosis pathway, including the activation of caspases 3, and 9 and poly (ADP-ribose) polymerase (PARP). These results suggested that SPP may prevent the development and progression of atherosclerosis and leukemia in humans. View Full-Text
Keywords: Peltophorum pterocarpum; anti-oxidant; LDL; human leukemia cancer cells; caspases Peltophorum pterocarpum; anti-oxidant; LDL; human leukemia cancer cells; caspases
Show Figures

Figure 1

MDPI and ACS Style

Kim, S.-R.; Cuong To, D.; Nguyen, P.H.; Nguyen, Y.N.; Cho, B.-J.; Tran, M.H. Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant Peltophorum pterocarpum. Molecules 2020, 25, 4800. https://doi.org/10.3390/molecules25204800

AMA Style

Kim S-R, Cuong To D, Nguyen PH, Nguyen YN, Cho B-J, Tran MH. Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant Peltophorum pterocarpum. Molecules. 2020; 25(20):4800. https://doi.org/10.3390/molecules25204800

Chicago/Turabian Style

Kim, Seon-Rye, Dao Cuong To, Phi H. Nguyen, Yen N. Nguyen, Byung-Jun Cho, and Manh H. Tran 2020. "Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant Peltophorum pterocarpum" Molecules 25, no. 20: 4800. https://doi.org/10.3390/molecules25204800

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop