Next Article in Journal
Association of Moderate Beer Consumption with the Gut Microbiota and SCFA of Healthy Adults
Previous Article in Journal
Antibacterial Activity of Honey/Chitosan Nanofibers Loaded with Capsaicin and Gold Nanoparticles for Wound Dressing
Open AccessArticle

Two-Step One-Pot Reductive Amination of Furanic Aldehydes Using CuAlOx Catalyst in a Flow Reactor

Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(20), 4771; https://doi.org/10.3390/molecules25204771
Received: 26 September 2020 / Revised: 12 October 2020 / Accepted: 15 October 2020 / Published: 17 October 2020
Aminomethylhydroxymethylfuran derivatives are well known compounds which are used in the pharmaceutical industry. Reductive amination of 5-hydroxymethylfurfural (HMF) derived from available non-edible lignocellulosic biomass is an attractive method for the synthesis of this class of compounds. In the present study, the synthesis of N-substituted 5-(hydroxymethyl)-2-furfuryl amines and 5-(acetoxymethyl)-2-furfuryl amines was performed by two-step process, which includes the condensation of furanic aldehydes (HMF and 5-acetoxymethylfurfural) with primary amines in methanol on the first step and the reduction of obtained imines with hydrogen in a flow reactor over CuAlOx catalyst derived from layered double hydroxide on the second step. This process does not require isolation and purification of intermediate imines and can be used to synthesize a number of aminomethylhydroxymethylfurans in good to excellent yield. View Full-Text
Keywords: reductive amination; 5-hydroxymethylfurfural; 5-acetoxymethylfurfural; Cu-based catalyst; Cu-Al mixed oxide; primary amines; imine hydrogenation; flow reactor reductive amination; 5-hydroxymethylfurfural; 5-acetoxymethylfurfural; Cu-based catalyst; Cu-Al mixed oxide; primary amines; imine hydrogenation; flow reactor
Show Figures

Scheme 1

MDPI and ACS Style

Nuzhdin, A.L.; Bukhtiyarova, M.V.; Bukhtiyarov, V.I. Two-Step One-Pot Reductive Amination of Furanic Aldehydes Using CuAlOx Catalyst in a Flow Reactor. Molecules 2020, 25, 4771.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop