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Review

Telodendrimers: Promising Architectural Polymers for Drug Delivery

Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada
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Academic Editor: Carlos Alemán
Molecules 2020, 25(17), 3995; https://doi.org/10.3390/molecules25173995
Received: 26 July 2020 / Revised: 27 August 2020 / Accepted: 28 August 2020 / Published: 2 September 2020
Architectural complexity has played a key role in enhancing the efficacy of nanocarriers for a variety of applications, including those in the biomedical field. With the continued evolution in designing macromolecules-based nanoparticles for drug delivery, the combination approach of using important features of linear polymers with dendrimers has offered an advantageous and viable platform. Such nanostructures, which are commonly referred to as telodendrimers, are hybrids of linear polymers covalently linked with different dendrimer generations and backbones. There is considerable variety in selection from widely studied linear polymers and dendrimers, which can help tune the overall composition of the resulting hybrid structures. This review highlights the advances in articulating syntheses of these macromolecules, and the contributions these are making in facilitating therapeutic administration. Limited progress has been made in the design and synthesis of these hybrid macromolecules, and it is through an understanding of their physicochemical properties and aqueous self-assembly that one can expect to fully exploit their potential in drug delivery. View Full-Text
Keywords: telodendrimer; dendrimers; linear polymers; hybrid structures; drug delivery; micelles; nanoformulations; soft nanoparticles; macromolecules telodendrimer; dendrimers; linear polymers; hybrid structures; drug delivery; micelles; nanoformulations; soft nanoparticles; macromolecules
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MDPI and ACS Style

Mejlsøe, S.; Kakkar, A. Telodendrimers: Promising Architectural Polymers for Drug Delivery. Molecules 2020, 25, 3995. https://doi.org/10.3390/molecules25173995

AMA Style

Mejlsøe S, Kakkar A. Telodendrimers: Promising Architectural Polymers for Drug Delivery. Molecules. 2020; 25(17):3995. https://doi.org/10.3390/molecules25173995

Chicago/Turabian Style

Mejlsøe, Søren, and Ashok Kakkar. 2020. "Telodendrimers: Promising Architectural Polymers for Drug Delivery" Molecules 25, no. 17: 3995. https://doi.org/10.3390/molecules25173995

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