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Article

Strong Positive Correlation between TSH and Ghrelin in Euthyroid Non-Growth Hormone-Deficient Children with Short Stature

1
Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland
2
Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland
3
Department of Pediatric Endocrinology, Medical University of Lodz, 93-338 Lodz, Poland
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(17), 3912; https://doi.org/10.3390/molecules25173912
Received: 14 July 2020 / Revised: 19 August 2020 / Accepted: 25 August 2020 / Published: 27 August 2020
The growth processes in children depend on the proper functioning of some hormones and growth factors. Recently, a positive correlation between ghrelin and TSH (thyroid stimulating hormone) in patients with hyper- and hypothyroidism was proved. Moreover, in hypothyroid rats with high ghrelin concentration, growth hormone (GH) and insulin-like growth factor I (IGF-I) secretion was suppressed. We analyzed these relationships in euthyroid prepubertal children with idiopathic short stature (ISS). The analysis comprised concentration of ghrelin, GH in stimulating tests and during the night, as well as IGF-I, TSH, free thyroxine (FT4) and free triiodothyronine (FT3) in 85 children with ISS (36 girls, 49 boys) aged 9.65 ± 3.02 years (mean ± SD). A strong positive correlation between ghrelin and TSH was confirmed (r = +0.44, p < 0.05). A higher ghrelin but lower nocturnal GH and lower IGF-I were observed in children with higher normal TSH concentration than those in children with lower normal TSH. Interestingly, alterations of TSH level were without any impact on FT4 and FT3 concentrations. Summing up, in ISS prepubertal euthyroid children, ghrelin and TSH secretion are closely related. On the other hand, the higher the TSH, the lower the nocturnal GH and IGF-I levels. The contribution of the above findings in deterioration of growth processes requires further studies. View Full-Text
Keywords: ghrelin; growth hormone; thyroid stimulating hormone; free thyroxine; free triiodothyronine; insulin-like growth factor I; idiopathic short stature; children ghrelin; growth hormone; thyroid stimulating hormone; free thyroxine; free triiodothyronine; insulin-like growth factor I; idiopathic short stature; children
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MDPI and ACS Style

Adamczewska, K.; Adamczewski, Z.; Łupińska, A.; Lewiński, A.; Stawerska, R. Strong Positive Correlation between TSH and Ghrelin in Euthyroid Non-Growth Hormone-Deficient Children with Short Stature. Molecules 2020, 25, 3912. https://doi.org/10.3390/molecules25173912

AMA Style

Adamczewska K, Adamczewski Z, Łupińska A, Lewiński A, Stawerska R. Strong Positive Correlation between TSH and Ghrelin in Euthyroid Non-Growth Hormone-Deficient Children with Short Stature. Molecules. 2020; 25(17):3912. https://doi.org/10.3390/molecules25173912

Chicago/Turabian Style

Adamczewska, Katarzyna, Zbigniew Adamczewski, Anna Łupińska, Andrzej Lewiński, and Renata Stawerska. 2020. "Strong Positive Correlation between TSH and Ghrelin in Euthyroid Non-Growth Hormone-Deficient Children with Short Stature" Molecules 25, no. 17: 3912. https://doi.org/10.3390/molecules25173912

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