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A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice

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Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
2
State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
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Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
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School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
5
Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Helen Osborn
Molecules 2020, 25(16), 3730; https://doi.org/10.3390/molecules25163730
Received: 20 July 2020 / Revised: 11 August 2020 / Accepted: 13 August 2020 / Published: 15 August 2020
(This article belongs to the Section Medicinal Chemistry)
Tricin, a flavone isolated from rice bran, has been shown to be chemopreventive in a colorectal cancer (CRC) mouse model. This study aimed to illustrate the inhibitory activities of tricin in colon cancer cells and in a metastatic CRC mouse model. BALB/c mice injected with mouse Colon26-Luc cells into the rectum wall were treated with tricin (37.5 mg/kg) daily for 18 days. Orthotopic colon tumor growth and metastasis to lungs were assessed by in vivo bioluminescence imaging. Results showed that tricin suppressed Colon-Luc cells motility and downregulated phosphorylated Akt, Erk1/2 and NF-κB expressions of human colon cancer HT-29 cells. While tricin treatment suppressed tumor growth and lung metastasis as well as altered the populations of myeloid-derived suppressor cells and regulatory T cells in spleens. In summary, the tumor microenvironment modulatory and anti-metastatic effects of tricin in colon cancer mouse model were shown for the first time, suggesting the potential development of tricin-containing food supplements for CRC patients. View Full-Text
Keywords: colorectal cancer; tricin; flavone; grains; anti-tumor; anti-metastasis colorectal cancer; tricin; flavone; grains; anti-tumor; anti-metastasis
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MDPI and ACS Style

Yue, G.G.-L.; Gao, S.; Lee, J.K.-M.; Chan, Y.-Y.; Wong, E.C.-W.; Zheng, T.; Li, X.-X.; Shaw, P.-C.; Simmonds, M.S.J.; Lau, C.B.-S. A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice. Molecules 2020, 25, 3730. https://doi.org/10.3390/molecules25163730

AMA Style

Yue GG-L, Gao S, Lee JK-M, Chan Y-Y, Wong EC-W, Zheng T, Li X-X, Shaw P-C, Simmonds MSJ, Lau CB-S. A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice. Molecules. 2020; 25(16):3730. https://doi.org/10.3390/molecules25163730

Chicago/Turabian Style

Yue, Grace G.-L., Si Gao, Julia K.-M. Lee, Yuk-Yu Chan, Eric C.-W. Wong, Tao Zheng, Xiao-Xiao Li, Pang-Chui Shaw, Monique S.J. Simmonds, and Clara B.-S. Lau 2020. "A Natural Flavone Tricin from Grains Can Alleviate Tumor Growth and Lung Metastasis in Colorectal Tumor Mice" Molecules 25, no. 16: 3730. https://doi.org/10.3390/molecules25163730

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