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Article

Potential of Naftifine Application for Transungual Delivery

1
Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukilėlių pr. 13, Kaunas 50161, Lithuania
2
Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukilėlių pr. 13, Kaunas 50161, Lithuania
*
Author to whom correspondence should be addressed.
Academic Editor: Silvia Panzavolta
Molecules 2020, 25(13), 3043; https://doi.org/10.3390/molecules25133043
Received: 17 May 2020 / Revised: 29 June 2020 / Accepted: 30 June 2020 / Published: 3 July 2020
(This article belongs to the Special Issue Applications of Materials in Drug Delivery)
Naftifine is used to treat fungal skin infections as it inhibits dermatophytes, which are the cause of onychomycosis. However, naftifine’s ability to permeate the human nail barrier has not been investigated, thus, the antimycotic potential is not clearly established. This work aims to evaluate the effect of penetration enhancing factors on the accumulation of naftifine hydrochloride through human nail clippings. Naftifine polymeric nail lacquers with Eudragit RL100 were developed as a suitable delivery system. Low penetration of naftifine into nail has been determined as less than 10% of applied drug dose accumulated in the nail layers. Incorporation of thioglycolic acid into formulations resulted in increased accumulation of antifungal agent in the nail layers by 100% compared with a control group. Salicylic acid did not effect naftifine accumulation in the human nail. The permeation of naftifine through the nail increased by threefold when the thioglycolic acid-containing formulation was applied and the nail was pretreated with a fractional CO2 laser. Structural changes of the nail barrier, induced by fractional CO2 laser, were visualized by microscopy. The results suggest, that naftifine nail penetration could be significantly increased when physical and chemical enhancing factors are applied. View Full-Text
Keywords: transungual delivery; polymeric nail lacquers; naftifine; chemical enhancement; fractional laser; onychomycosis transungual delivery; polymeric nail lacquers; naftifine; chemical enhancement; fractional laser; onychomycosis
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MDPI and ACS Style

Šveikauskaitė, I.; Briedis, V. Potential of Naftifine Application for Transungual Delivery. Molecules 2020, 25, 3043. https://doi.org/10.3390/molecules25133043

AMA Style

Šveikauskaitė I, Briedis V. Potential of Naftifine Application for Transungual Delivery. Molecules. 2020; 25(13):3043. https://doi.org/10.3390/molecules25133043

Chicago/Turabian Style

Šveikauskaitė, Indrė, and Vitalis Briedis. 2020. "Potential of Naftifine Application for Transungual Delivery" Molecules 25, no. 13: 3043. https://doi.org/10.3390/molecules25133043

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