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Open AccessArticle

Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners

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Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
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School of Pharmacy, University of the Western Cape, Bellville 7535, South Africa
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SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
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Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
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Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Rondebosch 7701, South Africa
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Department of Molecular and Cell Biology, University of Cape Town, Rondebosch 7701, South Africa
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College of Science, University of the Philippines Cebu, Lahug, Cebu City 6000, Philippines
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Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(13), 2979; https://doi.org/10.3390/molecules25132979
Received: 21 May 2020 / Revised: 4 June 2020 / Accepted: 9 June 2020 / Published: 29 June 2020
(This article belongs to the Section Natural Products Chemistry)
In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D1 2, have been isolated, together with four known hydroxamates, desferrioxamine D1 3, desferrioxamine B 4, desoxy-nocardamine 5 and nocardamine 6, and a diketopiperazine (DKP) 7. The structures of 17 were characterized by the analysis of HRESIMS and 1D and 2D NMR data, as well as by comparison with the relevant literature. Three new dehydroxy desferrioxamine derivatives 810 were tentatively identified in the molecular network of K. speibonae strain SK5 extracts, and structures were proposed based on their MS/MS fragmentation patterns. A plausible spb biosynthetic pathway was proposed. To the best of our knowledge, this is the first report of the isolation of desferrioxamines from the actinobacterial genus Kribbella. View Full-Text
Keywords: Kribbella; speibonoxamine; siderophore; hydroxamate; molecular networking; mass spectrometry Kribbella; speibonoxamine; siderophore; hydroxamate; molecular networking; mass spectrometry
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Acquah, K.S.; Beukes, D.R.; Warner, D.F.; Meyers, P.R.; Sunassee, S.N.; Maglangit, F.; Deng, H.; Jaspars, M.; Gammon, D.W. Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners. Molecules 2020, 25, 2979.

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