Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Experimental Design
4.2. Blood Collection and Metabolomics’ Measurement
4.3. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
Arg | arginine |
Asp | aspartate |
BCAAs | branched-chain amino acids |
C0 | carnitine (free) |
C2 | acetylcarnitine |
C3 | propionylcarnitine |
C3-DC | malonylcarnitine |
C4-DC | methylmalonylcarnitine |
C4-OH | hydroxybutyrylcarnitine |
C4-OH-Pro | cis-4-hydroxyproline |
C5-OH | hydroxyvalerylcarnitine |
C6 | hexanoylcarnitine |
C6-DC | methylglutarylcarnitine |
C6:1 | hexenoylcarnitine |
C8 | octanoylcarnitine |
C8-DC | suberylcarnitine |
C10 | decanoylcarnitine |
C10:2 | decadienoylcarnitine |
C10-DC | decanedioylcarnitine |
C12 | dodecanoylcarnitine |
C12-OH | 3-hydroxydodecanoylcarnitine |
C14 | myristylcarnitine |
C14:1 | myristoleylcarnitine |
C14:2 | tetradecadienoylcarnitine |
C14-OH | 3-hydroxytetradecanoylcarnitine |
C16 | palmitoylcarnitine |
C16:1 | palmitoleylcarnitine |
C16-OH | hydroxypalmitoylcarnitine |
C16:1-OH | hydroxypalmitoleylcarnitine |
C18 | stearylcarnitine |
C18:2 | linoleylcarnitine |
C18:1-OH | hydroxyoleylcarnitine |
FAs | fatty acids |
FDR | false discovery rate |
Gln | glutamine |
Gly | glycine |
Ile | isoleucine |
Leu | leucine |
Met | methionine |
Met-So | methionine-sulfoxide |
Orn | ornithine |
Phe | phenylalanine |
Pro | proline |
SAM | significance analysis of metabolites |
SDMA | symmetric dimethylarginine |
Ser | serine |
Trp | tryptophan |
Tyr | tyrosine |
t4-OH-Pro | trans-4-hydroxyproline |
Val | valine |
VIP | variance importance in projection |
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Sample Availability: Samples are not available from the authors. |
Compound | d Value | SD | Raw p | q Value |
---|---|---|---|---|
C0 | 5.5527 | 0.27896 | 0 | 0 |
Tyr | 4.0661 | 0.33172 | 0.00025 | 0.0059235 |
C5-OH (C3-DC-M) | 3.8686 | 0.33952 | 0.000625 | 0.0098725 |
Orn | 3.4304 | 0.35729 | 0.001375 | 0.014216 |
Gly | 3.3856 | 0.35913 | 0.0015 | 0.014216 |
C4 | 2.6289 | 0.39057 | 0.01525 | 0.099959 |
C6 (C4:1-DC) | 2.5906 | 0.39214 | 0.016875 | 0.099959 |
Compound | t Stat | p Value | −log10(p) | FDR |
---|---|---|---|---|
C0 | −5.5527 | 0.000028526 | 4.5448 | 0.0022821 |
Tyr | −4.0661 | 0.00072486 | 3.1397 | 0.028994 |
C5-OH (C3-DC-M) | −3.8686 | 0.0011255 | 2.9486 | 0.030014 |
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Leskanicova, A.; Chovancova, O.; Babincak, M.; Verboova, L.; Benetinova, Z.; Macekova, D.; Kostolny, J.; Smajda, B.; Kiskova, T. Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis. Molecules 2020, 25, 2353. https://doi.org/10.3390/molecules25102353
Leskanicova A, Chovancova O, Babincak M, Verboova L, Benetinova Z, Macekova D, Kostolny J, Smajda B, Kiskova T. Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis. Molecules. 2020; 25(10):2353. https://doi.org/10.3390/molecules25102353
Chicago/Turabian StyleLeskanicova, Andrea, Olga Chovancova, Marian Babincak, Ludmila Verboova, Zuzana Benetinova, Denisa Macekova, Jozef Kostolny, Benadik Smajda, and Terezia Kiskova. 2020. "Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis" Molecules 25, no. 10: 2353. https://doi.org/10.3390/molecules25102353