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Article

Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies

Division for Nanotechnology and Functional Materials, Department of Engineering Sciences, SE-751 21 Uppsala, Sweden
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Molecules 2019, 24(9), 1820; https://doi.org/10.3390/molecules24091820
Received: 10 April 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 11 May 2019
Salicylic acid (SA) has for a long time been used to treat various skin disorders due to its anti-inflammatory, bacteriostatic, and antifungal properties. In the present work, mesoporous magnesium carbonate (MMC), a promising drug carrier, was modified with 3-aminopropyl-triethoxysilane to enable loading of SA. The amine modified MMC (aMMC) was successfully loaded with 8 wt.% of SA via a solvent evaporation method. SA was later completely released from the carrier in less than 15 min. Furthermore, the cytotoxicity of the functionalized material was evaluated. aMMC was found to be non-toxic for human dermal fibroblast cells with particle concentration of up to 1000 µg/mL when exposed for 48 h. The presented results form the basis of future development of aMMC as a potential carrier for SA in dermatological applications. View Full-Text
Keywords: mesoporous; magnesium carbonate; amine functionalization; cytotoxicity; salicylic acid; drug release mesoporous; magnesium carbonate; amine functionalization; cytotoxicity; salicylic acid; drug release
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MDPI and ACS Style

Vall, M.; Ferraz, N.; Cheung, O.; Strømme, M.; Zardán Gómez de la Torre, T. Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies. Molecules 2019, 24, 1820. https://doi.org/10.3390/molecules24091820

AMA Style

Vall M, Ferraz N, Cheung O, Strømme M, Zardán Gómez de la Torre T. Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies. Molecules. 2019; 24(9):1820. https://doi.org/10.3390/molecules24091820

Chicago/Turabian Style

Vall, Maria, Natalia Ferraz, Ocean Cheung, Maria Strømme, and Teresa Zardán Gómez de la Torre. 2019. "Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies" Molecules 24, no. 9: 1820. https://doi.org/10.3390/molecules24091820

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