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Open AccessArticle

Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing

1
DiSIT—Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy
2
Department of Molecular Medicine, Human Physiology Unit, University of Pavia, 27100 Pavia, Italy
3
DiSIT—Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Piazza Sant’Eusebio 5, 13100 Vercelli, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Juraj Majtan
Molecules 2019, 24(8), 1544; https://doi.org/10.3390/molecules24081544
Received: 20 March 2019 / Revised: 15 April 2019 / Accepted: 18 April 2019 / Published: 19 April 2019
(This article belongs to the Special Issue Biological Activities of Honeybee Products)
Propolis is the generic name of a complex of resinous compound collected by honeybees and it has been utilized for many years in folk medicine. As other products generated by honeybees (such as royal jelly, pollen, honey), propolis has great therapeutic properties, but very little scientific information is available. Therefore, this study was aimed at exploring the potential wound healing properties of propolis. To that end, we utilized an in vitro scratch wound healing model consisting of human immortalized keratinocytes. Our scratch wound data clearly demonstrated that propolis induced a pronounced increase in the wound repair abilities of keratinocytes. A cell migration assay showed that propolis stimulated keratinocytes to close the wound. We revealed the role of H2O2 as the main mediator of propolis regenerative properties. We showed that this extracellularly released H2O2 could pass across the plasma membrane through a specific aquaporin (i.e., AQP3) modulating intracellular responses. The data offer a biological characterization of propolis positive effects suggesting that propolis could also be utilized in wound treatment within clinical settings. View Full-Text
Keywords: aquaporin-3; ROS; migration; propolis; wound repair aquaporin-3; ROS; migration; propolis; wound repair
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MDPI and ACS Style

Martinotti, S.; Pellavio, G.; Laforenza, U.; Ranzato, E. Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing. Molecules 2019, 24, 1544.

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