Next Article in Journal
Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics
Next Article in Special Issue
Different adaptive NO-dependent Mechanisms in Normal and Hypertensive Conditions
Previous Article in Journal
A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS)
Previous Article in Special Issue
Cardiac-Specific Cre Induces Age-Dependent Dilated Cardiomyopathy (DCM) in Mice
Open AccessReview

The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease

1
Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovak Republic
2
Institute of Cardiovascular Sciences and the Canadian Centre for Agri-food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H2A6, Canada
3
Department of Physiology and Pathophysiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E0W3, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Morris Karmazyn
Molecules 2019, 24(8), 1509; https://doi.org/10.3390/molecules24081509
Received: 18 March 2019 / Revised: 12 April 2019 / Accepted: 15 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Cardiovascular Diseases Prevention and Therapy)
Food quality and nutritional habits strongly influence human health status. Extensive research has been conducted to confirm that foods rich in biologically active nutrients have a positive impact on the onset and development of different pathological processes, including cardiovascular diseases. However, the underlying mechanisms by which dietary compounds regulate cardiovascular function have not yet been fully clarified. A growing number of studies confirm that bioactive food components modulate various signaling pathways which are involved in heart physiology and pathology. Recent evidence indicates that microRNAs (miRNAs), small single-stranded RNA chains with a powerful ability to influence protein expression in the whole organism, have a significant role in the regulation of cardiovascular-related pathways. This review summarizes recent studies dealing with the impact of some biologically active nutrients like polyunsaturated fatty acids (PUFAs), vitamins E and D, dietary fiber, or selenium on the expression of many miRNAs, which are connected with cardiovascular diseases. Current research indicates that the expression levels of many cardiovascular-related miRNAs like miRNA-21, -30 family, -34, -155, or -199 can be altered by foods and dietary supplements in various animal and human disease models. Understanding the dietary modulation of miRNAs represents, therefore, an important field for further research. The acquired knowledge may be used in personalized nutritional prevention of cardiovascular disease or the treatment of cardiovascular disorders. View Full-Text
Keywords: bioactive food components; cardiovascular disease; heart; miRNA; nutrition bioactive food components; cardiovascular disease; heart; miRNA; nutrition
Show Figures

Figure 1

MDPI and ACS Style

Kura, B.; Parikh, M.; Slezak, J.; Pierce, G.N. The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease. Molecules 2019, 24, 1509. https://doi.org/10.3390/molecules24081509

AMA Style

Kura B, Parikh M, Slezak J, Pierce GN. The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease. Molecules. 2019; 24(8):1509. https://doi.org/10.3390/molecules24081509

Chicago/Turabian Style

Kura, Branislav; Parikh, Mihir; Slezak, Jan; Pierce, Grant N. 2019. "The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease" Molecules 24, no. 8: 1509. https://doi.org/10.3390/molecules24081509

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop