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Molecules 2019, 24(8), 1468; https://doi.org/10.3390/molecules24081468

Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from Oxytropis chiliophylla

1
State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2
National Anti-Doping Laboratory, China Anti-Doping Agency, Beijing 100029, China
3
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
4
Research Center, School of Medicine, Tianjin Tianshi College, Tianyuan University, Tianjin 301700, China
*
Authors to whom correspondence should be addressed.
Received: 21 March 2019 / Revised: 10 April 2019 / Accepted: 11 April 2019 / Published: 13 April 2019
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Abstract

Three previously undescribed biflavonoids, oxytrodiflavanone A (1), and oxytrochalcoflavanones A,B (2,3), were isolated from the aerial part of Oxytropis chiliophylla, together with their putative biosynthetic monomers, i.e., (2S)-5,7-dihydroxyflavanone (4), (2S)-7-hydroxyflavanone (5), and 2′,4′-dihydroxychalcone (6). The structures of these compounds were elucidated by a combination analysis of spectroscopic data. The cytotoxic activities of all the isolated compounds against PC-3 human prostate cancer cell line are also presented. View Full-Text
Keywords: Oxytropis chiliophylla; Oxytropis; biflavonoids Oxytropis chiliophylla; Oxytropis; biflavonoids
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Liu, Y.; Kelsang, N.; Lu, J.; Zhang, Y.; Liang, H.; Tu, P.; Kong, D.; Zhang, Q. Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from Oxytropis chiliophylla. Molecules 2019, 24, 1468.

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