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Molecules 2019, 24(8), 1468;

Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from Oxytropis chiliophylla

State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
National Anti-Doping Laboratory, China Anti-Doping Agency, Beijing 100029, China
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
Research Center, School of Medicine, Tianjin Tianshi College, Tianyuan University, Tianjin 301700, China
Authors to whom correspondence should be addressed.
Received: 21 March 2019 / Revised: 10 April 2019 / Accepted: 11 April 2019 / Published: 13 April 2019
PDF [858 KB, uploaded 13 April 2019]


Three previously undescribed biflavonoids, oxytrodiflavanone A (1), and oxytrochalcoflavanones A,B (2,3), were isolated from the aerial part of Oxytropis chiliophylla, together with their putative biosynthetic monomers, i.e., (2S)-5,7-dihydroxyflavanone (4), (2S)-7-hydroxyflavanone (5), and 2′,4′-dihydroxychalcone (6). The structures of these compounds were elucidated by a combination analysis of spectroscopic data. The cytotoxic activities of all the isolated compounds against PC-3 human prostate cancer cell line are also presented. View Full-Text
Keywords: Oxytropis chiliophylla; Oxytropis; biflavonoids Oxytropis chiliophylla; Oxytropis; biflavonoids

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Liu, Y.; Kelsang, N.; Lu, J.; Zhang, Y.; Liang, H.; Tu, P.; Kong, D.; Zhang, Q. Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from Oxytropis chiliophylla. Molecules 2019, 24, 1468.

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