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Molecules 2019, 24(7), 1224;

Microwave-Driven Synthesis of Iron-Oxide Nanoparticles for Molecular Imaging

NanoMedMol Group, Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (CSIC) and CIBERES, C/Juan de la Cierva 3, 28006 Madrid, Spain
Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de ramón y Cajal, 28040 Madrid, Spain
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), C/Melchor Fernández-Almagro 3, 28029 Madrid, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: John Spencer
Received: 15 February 2019 / Revised: 21 March 2019 / Accepted: 25 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Microwave-mediated Chemistry)
PDF [7687 KB, uploaded 28 March 2019]


Here, we present a comprehensive review on the use of microwave chemistry for the synthesis of iron-oxide nanoparticles focused on molecular imaging. We provide a brief introduction on molecular imaging, the applications of iron oxide in biomedicine, and traditional methods for the synthesis of these nanoparticles. The review then focuses on the different examples published where the use of microwaves is key for the production of nanoparticles. We study how the different parameters modulate nanoparticle properties, particularly for imaging applications. Finally, we explore principal applications in imaging of microwave-produced iron-oxide nanoparticles. View Full-Text
Keywords: iron-oxide nanoparticles; molecular imaging; magnetic resonance imaging (MRI); positron-emission tomography (PET) iron-oxide nanoparticles; molecular imaging; magnetic resonance imaging (MRI); positron-emission tomography (PET)

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fernández-Barahona, I.; Muñoz-Hernando, M.; Herranz, F. Microwave-Driven Synthesis of Iron-Oxide Nanoparticles for Molecular Imaging. Molecules 2019, 24, 1224.

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