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Chiral Selectors in Capillary Electrophoresis: Trends during 2017–2018

Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences-Chemistry, University of Tasmania, Hobart, 7001 Tasmania, Australia
Author to whom correspondence should be addressed.
Academic Editor: Eric Peyrin
Molecules 2019, 24(6), 1135;
Received: 27 February 2019 / Revised: 16 March 2019 / Accepted: 19 March 2019 / Published: 21 March 2019
(This article belongs to the Section Analytical Chemistry)
PDF [2622 KB, uploaded 27 March 2019]


Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates. View Full-Text
Keywords: chiral separation; capillary electrophoresis; electrokinetic chromatography; macromolecules; supramolecules chiral separation; capillary electrophoresis; electrokinetic chromatography; macromolecules; supramolecules

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Yu, R.B.; Quirino, J.P. Chiral Selectors in Capillary Electrophoresis: Trends during 2017–2018. Molecules 2019, 24, 1135.

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