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Molecules 2019, 24(6), 1007; https://doi.org/10.3390/molecules24061007

Enantiomeric Recognition and Separation by Chiral Nanoparticles

1
Department of Physics, Jagannath Barooah College, Jorhat, Assam 785001, India
2
Department of Biophysics, School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
3
Department of Chemistry, Dibrugarh University, Dibrugarh, Assam 786004, India
4
Institute of New Drug Development, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan
5
Integrative Stem Cell Center, China Medical University Hospital, No. 2, Yude Rd., Taichung 40447, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Maria Elizabeth Tiritan, Madalena Pinto and Carla Sofia Garcia Fernandes
Received: 3 February 2019 / Revised: 5 March 2019 / Accepted: 10 March 2019 / Published: 13 March 2019
Full-Text   |   PDF [3171 KB, uploaded 13 March 2019]   |  

Abstract

Chiral molecules are stereoselective with regard to specific biological functions. Enantiomers differ considerably in their physiological reactions with the human body. Safeguarding the quality and safety of drugs requires an efficient analytical platform by which to selectively probe chiral compounds to ensure the extraction of single enantiomers. Asymmetric synthesis is a mature approach to the production of single enantiomers; however, it is poorly suited to mass production and allows for only specific enantioselective reactions. Furthermore, it is too expensive and time-consuming for the evaluation of therapeutic drugs in the early stages of development. These limitations have prompted the development of surface-modified nanoparticles using amino acids, chiral organic ligands, or functional groups as chiral selectors applicable to a racemic mixture of chiral molecules. The fact that these combinations can be optimized in terms of sensitivity, specificity, and enantioselectivity makes them ideal for enantiomeric recognition and separation. In chiral resolution, molecules bond selectively to particle surfaces according to homochiral interactions, whereupon an enantiopure compound is extracted from the solution through a simple filtration process. In this review article, we discuss the fabrication of chiral nanoparticles and look at the ways their distinctive surface properties have been adopted in enantiomeric recognition and separation. View Full-Text
Keywords: chirality; racemic mixture; enantiomer; enantiomeric recognition; enantiomeric separation; surface-modified nanoparticle; chiral ligand chirality; racemic mixture; enantiomer; enantiomeric recognition; enantiomeric separation; surface-modified nanoparticle; chiral ligand
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gogoi, A.; Mazumder, N.; Konwer, S.; Ranawat, H.; Chen, N.-T.; Zhuo, G.-Y. Enantiomeric Recognition and Separation by Chiral Nanoparticles. Molecules 2019, 24, 1007.

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