Next Article in Journal
The Extracts of Artemisia absinthium L. Suppress the Growth of Hepatocellular Carcinoma Cells through Induction of Apoptosis via Endoplasmic Reticulum Stress and Mitochondrial-Dependent Pathway
Previous Article in Journal
Supercritical CO2 Fluid Extraction of Elaeagnus mollis Diels Seed Oil and Its Antioxidant Ability
Article Menu
Issue 5 (March-1) cover image

Export Article

Open AccessArticle

Comparison among Activities and Isoflavonoids from Pueraria thunbergiana Aerial Parts and Root

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
Division of Bio-Technology and Convergence, Daegu Haany University, 285-10 Eobongji-gil, Gyeongsan, Gyeongsangbuk-do 38578, Korea
Department of Microbiology, Faculty of Natural Science, Dankook University, Cheonan, Chungnam 31116, Korea
Authors to whom correspondence should be addressed.
Dong-Seon Kim and Gyeong-Yup Chi contributed equally to this work.
Molecules 2019, 24(5), 912;
Received: 7 February 2019 / Revised: 25 February 2019 / Accepted: 25 February 2019 / Published: 5 March 2019
PDF [2284 KB, uploaded 18 March 2019]
  |     |  


Kudzu (Pueraria thunbergiana Benth.) has long been used as a food and medicine for many centuries. The root is the most commonly used portion of the plant, but the aerial parts are occasionally used as well. In this study, we investigated the constituent compounds and biological activities of the aerial parts, leaves, stems, and sprouts, and compared their constituents and activities with those of roots. Leaf extract showed a significantly higher TPC level at 59 ± 1.6 mg/g and lower free radical scavenging (FRS) values under 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), and NO inhibition at 437 ± 11, 121 ± 6.6 μg/mL and 107 ± 4.9 μg/mL, respectively, than those of sprout, stem, and root extract. Leaf extract also significantly suppressed lipopolysaccharide (LPS)-mediated gene expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). The main components of leaf extract were found to be genistin and daidzin. This study suggests that the leaves of kudzu are a good source of biological activities and isoflavones that can be used in functional or medicinal foods and cosmetics for the prevention or treatment of diseases related to inflammation and oxidative stress. View Full-Text
Keywords: Pueraria thunbergiana; phenolic content; NO; iNOS; COX-2; kudzu leaves Pueraria thunbergiana; phenolic content; NO; iNOS; COX-2; kudzu leaves

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Son, E.; Yoon, J.-M.; An, B.-J.; Lee, Y.M.; Cha, J.; Chi, G.-Y.; Kim, D.-S. Comparison among Activities and Isoflavonoids from Pueraria thunbergiana Aerial Parts and Root. Molecules 2019, 24, 912.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top