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Open AccessArticle

New Metabolic Influencer on Oxytocin Release: The Ghrelin

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Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
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Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, University Of Szeged, Szeged, Hungary
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Institute of Physical Education and Sport Sciences, Gyula Juhász Faculty of Education, University of Szeged, 6725 Szeged, Hungary
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Department of Medical Chemistry, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary
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First Department of Internal Medicine, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary
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Department of Environmental Biology and Education, Gyula Juhász Faculty of Education, Institute of Applied Science, University of Szeged, 6725 Szeged, Hungary
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Department of Psychiatry, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary
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HR-Pharma Ltd., 6726 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Renáta Szabó and Rudolf Ménesi contributed equally to this paper as first authors.
The author was deceased.
Academic Editor: Béla Juhász
Molecules 2019, 24(4), 735; https://doi.org/10.3390/molecules24040735
Received: 28 January 2019 / Revised: 11 February 2019 / Accepted: 13 February 2019 / Published: 18 February 2019
(This article belongs to the Special Issue Bioactive Compounds for Metabolic Syndrome and Type 2 Diabetes-II)
Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [d-Lys3]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [d-Lys3]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options. View Full-Text
Keywords: ghrelin; ghrelin antagonist; oxytocin; neuropeptide regulation ghrelin; ghrelin antagonist; oxytocin; neuropeptide regulation
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Szabó, R.; Ménesi, R.; H. Molnár, A.; Szalai, Z.; Daruka, L.; Tóth, G.; Gardi, J.; Gálfi, M.; Börzsei, D.; Kupai, K.; Juhász, A.; Radács, M.; László, F.A.; Varga, C.; Pósa, A. New Metabolic Influencer on Oxytocin Release: The Ghrelin. Molecules 2019, 24, 735.

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