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Molecules 2019, 24(4), 658; https://doi.org/10.3390/molecules24040658

Graphene-Based Nanocomposites for Neural Tissue Engineering

1,†
,
1,2,†
,
1
,
1
,
3
,
1,*
and
1,*
1
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong, China
2
Department of Mechanical Engineering, National University of Singapore (NUS), Singapore 117575, Singapore
3
Department of Preventive Medicine, School of Public Health, Chengdu Medical College, Chengdu 610500, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Ashok Kakkar
Received: 4 January 2019 / Revised: 31 January 2019 / Accepted: 11 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Graphene Nanocomposites)
Full-Text   |   PDF [2693 KB, uploaded 13 February 2019]   |  
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Abstract

Graphene has made significant contributions to neural tissue engineering due to its electrical conductivity, biocompatibility, mechanical strength, and high surface area. However, it demonstrates a lack of biological and chemical cues. Also, it may cause potential damage to the host body, limiting its achievement of efficient construction of neural tissues. Recently, there has been an increasing number of studies showing that combining graphene with other materials to form nano-composites can provide exceptional platforms for both stimulating neural stem cell adhesion, proliferation, differentiation and neural regeneration. This suggests that graphene nanocomposites are greatly beneficial in neural regenerative medicine. In this mini review, we will discuss the application of graphene nanocomposites in neural tissue engineering and their limitations, through their effect on neural stem cell differentiation and constructs for neural regeneration. View Full-Text
Keywords: graphene; nanocomposites; neural tissue engineering graphene; nanocomposites; neural tissue engineering
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Bei, H.P.; Yang, Y.; Zhang, Q.; Tian, Y.; Luo, X.; Yang, M.; Zhao, X. Graphene-Based Nanocomposites for Neural Tissue Engineering. Molecules 2019, 24, 658.

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