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Molecules 2019, 24(3), 625; https://doi.org/10.3390/molecules24030625

New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
These authors contributed equally to this work.
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Academic Editor: Derek J. McPhee
Received: 13 January 2019 / Revised: 1 February 2019 / Accepted: 3 February 2019 / Published: 11 February 2019
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1006 KB, uploaded 11 February 2019]   |  

Abstract

Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells. View Full-Text
Keywords: Cornus officinalis; iridoid; neuroprotective activity Cornus officinalis; iridoid; neuroprotective activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ji, L.-L.; Wang, X.; Li, J.-J.; Zhong, X.-J.; Zhang, B.; Juan, J.; Shang, X.-Y. New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities. Molecules 2019, 24, 625.

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