Next Article in Journal
Temperature-Dependent Evolution of Raman Spectra of Methylammonium Lead Halide Perovskites, CH3NH3PbX3 (X = I, Br)
Previous Article in Journal
Nanoformulation of a Novel Pyrano[2,3-c] Pyrazole Heterocyclic Compound AMDPC Exhibits Anti-Cancer Activity via Blocking the Cell Cycle through a P53-Independent Pathway
Article Menu
Issue 3 (February-1) cover image

Export Article

Open AccessArticle
Molecules 2019, 24(3), 625;

New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 13 January 2019 / Revised: 1 February 2019 / Accepted: 3 February 2019 / Published: 11 February 2019
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1006 KB, uploaded 11 February 2019]   |  


Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells. View Full-Text
Keywords: Cornus officinalis; iridoid; neuroprotective activity Cornus officinalis; iridoid; neuroprotective activity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Ji, L.-L.; Wang, X.; Li, J.-J.; Zhong, X.-J.; Zhang, B.; Juan, J.; Shang, X.-Y. New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities. Molecules 2019, 24, 625.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top