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Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors

Division of Development Technology, Graduate School for International Development and Cooperation (IDEC), Hiroshima University, Higashi Hiroshima 739-8529, Japan
Department of Biotechnology, NTT Institute of Hi-Technology, Nguyen Tat Thanh University, 298A-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City 72820, Vietnam
Central Institute of Medicinal and Aromatic Plants, Process Chemistry and Technology Department, Lucknow 226016, India
Khai Xuan International Co., Ltd., 22, 9/53/8 Quan Hoa, Cau Giay District, Hanoi 123000, Vietnam
Agricultural Genetics Institute, Pham Van Dong Street, Hanoi 122000, Vietnam
Center for Expert, Vietnam National University of Agriculture, Hanoi 131000, Vietnam
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, 63450 Hanau, Germany
Author to whom correspondence should be addressed.
Molecules 2019, 24(3), 482;
Received: 29 December 2018 / Accepted: 21 January 2019 / Published: 29 January 2019
(This article belongs to the Special Issue Discovery of Active Ingredients from Natural Products)
PDF [1380 KB, uploaded 29 January 2019]


Momilactones A (MA) and B (MB) are the active phytoalexins and allelochemicals in rice. In this study, MA and MB were purified from rice husk of Oryza sativa cv. Koshihikari by column chromatography, and purification was confirmed by high-performance liquid chromatography, thin-layer chromatography, gas chromatography-mass spectrometry, liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), and 1H and 13C nuclear magnetic resonance analyses. By in vitro assays, both MA and MB exerted potent inhibition on α-amylase and α-glucosidase activities. The inhibitory effect of MB on these two key enzymes was greater than that of MA. Both MA and MB exerted greater α-glucosidase suppression as compared to that of the commercial diabetic inhibitor acarbose. Quantities of MA and MB in rice grain were 2.07 ± 0.01 and 1.06 ± 0.01 µg/dry weight (DW), respectively. This study was the first to confirm the presence of MA and MB in refined rice grain and reported the α-amylase and α-glucosidase inhibitory activity of the two compounds. The improved protocol of LC-ESI-MS in this research was simple and effective to detect and isolate MA and MB in rice organs. View Full-Text
Keywords: momilactone A; momilactone B; rice grain; rice by-products; anti-diabetes; α-amylase; α-glucosidase; inhibitory activity momilactone A; momilactone B; rice grain; rice by-products; anti-diabetes; α-amylase; α-glucosidase; inhibitory activity

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Quan, N.V.; Tran, H.-D.; Xuan, T.D.; Ahmad, A.; Dat, T.D.; Khanh, T.D.; Teschke, R. Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors. Molecules 2019, 24, 482.

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