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Open AccessArticle

Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

1
Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Laboratory of Pharmacology of Pain and Inflammation, Rio de Janeiro 21941-902, Brazil
2
Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Graduate Program in Pharmacology and Medicinal Chemistry, Rio de Janeiro 21941-902, Brazil
3
Federal Rural University of Rio de Janeiro, Department of Chemistry, Seropédica 23890-000, Brazil
4
Federal University of Mato Grosso, Department of Chemistry, Cuiabá 78935-901, Brazil
5
Trinity College Dublin, Trinity Biomedical Sciences Institute, School of Pharmacy and Pharmaceutical Sciences, Dublin 2, Ireland
*
Author to whom correspondence should be addressed.
Academic Editors: Raffaele Capasso and Lorenzo Di Cesare Mannelli
Molecules 2019, 24(24), 4584; https://doi.org/10.3390/molecules24244584
Received: 4 November 2019 / Revised: 6 December 2019 / Accepted: 9 December 2019 / Published: 14 December 2019
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
Infusions of roots of Siolmatra brasiliensis (Cogn.) Baill, (“taiuiá”, “cipó-tauá”) are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of this plant and its isolated substances (cayaponoside A1, cayaponoside B4, cayaponoside D, and siolmatroside I). Hydroethanol extract (HE), ethyl acetate fraction (EtOAc), and isolated saponins were evaluated in chemical and thermal models of pain in mice. Animals were orally pretreated and evaluated in the capsaicin- or glutamate-induced licking and in the hot plate tests. The antinociceptive mechanism of action was evaluated using the hot plate test with the following pretreatments: Atropine (cholinergic antagonist), naloxone (opioid antagonist), or L-NAME (nitric oxide synthase inhibitor). All extracts and isolated saponins increased the area under the curve in the hot plate test. Tested substances induced a higher effect than the morphine-treated group. Our data suggest that stems of S. brasiliensis and their isolated substances present antinociceptive effects. Cholinergic and opioidergic pathways seem to be involved in their mechanism of action. Taken together our data corroborate the traditional use of the plant and expands the information regarding its use. View Full-Text
Keywords: Siolmatra brasiliensis; antinociceptive activity; cayaponoside A1; cayaponoside B4; cayaponoside D; siolmatroside I; pain; analgesia Siolmatra brasiliensis; antinociceptive activity; cayaponoside A1; cayaponoside B4; cayaponoside D; siolmatroside I; pain; analgesia
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MDPI and ACS Style

Giorno, T.B.S.; Santos, C.H.C.; Carvalho, M.G.; Silva, V.C.; Sousa, P.T., Jr.; Fernandes, P.D.; Boylan, F. Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill. Molecules 2019, 24, 4584.

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