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Functional Gene Network of Prenyltransferases in Arabidopsis thaliana

1
Institute of Biology and Ecology, Pavol Jozef Šafárik University in Košice, 04180 Košice, Slovakia
2
Institute of Pharmacology, University of Veterinary Medicine and Pharmacy in Košice, 04181 Košice, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editors: Ewa Swiezewska and Liliana Surmacz
Molecules 2019, 24(24), 4556; https://doi.org/10.3390/molecules24244556
Received: 7 November 2019 / Revised: 9 December 2019 / Accepted: 10 December 2019 / Published: 12 December 2019
(This article belongs to the Special Issue Plant Isoprenoids)
Prenyltransferases (PTs) are enzymes that catalyze prenyl chain elongation. Some are highly similar to each other at the amino acid level. Therefore, it is difficult to assign their function based solely on their sequence homology to functional orthologs. Other experiments, such as in vitro enzymatic assay, mutant analysis, and mutant complementation are necessary to assign their precise function. Moreover, subcellular localization can also influence the functionality of the enzymes within the pathway network, because different isoprenoid end products are synthesized in the cytosol, mitochondria, or plastids from prenyl diphosphate (prenyl-PP) substrates. In addition to in vivo functional experiments, in silico approaches, such as co-expression analysis, can provide information about the topology of PTs within the isoprenoid pathway network. There has been huge progress in the last few years in the characterization of individual Arabidopsis PTs, resulting in better understanding of their function and their topology within the isoprenoid pathway. Here, we summarize these findings and present the updated topological model of PTs in the Arabidopsis thaliana isoprenoid pathway. View Full-Text
Keywords: prenyltransferases; isoprenoid diphosphate synthases; product specificity; co-expression analysis; mutants; Arabidopsis prenyltransferases; isoprenoid diphosphate synthases; product specificity; co-expression analysis; mutants; Arabidopsis
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Kopcsayová, D.; Vranová, E. Functional Gene Network of Prenyltransferases in Arabidopsis thaliana. Molecules 2019, 24, 4556.

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