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Open AccessArticle

Taurochenodeoxycholic Acid Inhibited AP-1 Activation via Stimulating Glucocorticoid Receptor

by Lei Li 1, Chang Liu 1,*, Wei Mao 2, Bayaer Tumen 3 and Peifeng Li 2,*
1
Key Laboratory of Quality & Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China
2
Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rural, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
3
Shanxi Animal Disease Control Center, Taiyuan 030027, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2019, 24(24), 4513; https://doi.org/10.3390/molecules24244513
Received: 4 November 2019 / Revised: 30 November 2019 / Accepted: 7 December 2019 / Published: 10 December 2019
Taurochenodeoxycholic acid (TCDCA) as a primary bioactive substance of animal bile has been shown to exert good anti-inflammatory and immunomodulatory functions in adjuvant arthritis in rats. The anti-inflammatory and immunomodulatory properties of TCDCA have exhibited interesting similarities with the effects of glucocorticoids (GCs). To investigate the potential mechanisms of TCDCA in anti-inflammation and immunomodulation, we used a luciferase reporter assay to evaluate the activation of the glucocorticoid receptor (GR) stimulated by TCDCA. Our results showed that GR was activated by TCDCA in a concentration-dependent manner. Moreover, the elevated expressions of c-Fos and phosphorylated c-Jun induced by interleukin-1β (IL-1β) were reversed by TCDCA. The inhibition of TCDCA on the transactivation of activator protein-1 (AP-1) was observed as well. However, the suppression of TCDCA on the phosphorylation of c-Jun was blocked incompletely by GR inhibitor RU486. These results have indicated that the anti-inflammatory and immunomodulatory functions of TCDCA involve multiple pathways, with contributions from GR and its related AP-1 signaling pathway. View Full-Text
Keywords: taurochenodeoxycholic acid; activator protein-1; glucocorticoid receptor; anti-inflammation taurochenodeoxycholic acid; activator protein-1; glucocorticoid receptor; anti-inflammation
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MDPI and ACS Style

Li, L.; Liu, C.; Mao, W.; Tumen, B.; Li, P. Taurochenodeoxycholic Acid Inhibited AP-1 Activation via Stimulating Glucocorticoid Receptor. Molecules 2019, 24, 4513.

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