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Open AccessArticle

Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria

1
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2
Institute of TCM International Standardization of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3
Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Molecules 2019, 24(22), 4033; https://doi.org/10.3390/molecules24224033
Received: 22 October 2019 / Revised: 6 November 2019 / Accepted: 6 November 2019 / Published: 7 November 2019
(This article belongs to the Section Natural Products Chemistry)
As our ongoing research project on Ban Lan Gen (Isatis tinctoria roots), a total of 23 alkaloids were obtained. Compounds 1 and 2 contain an unusual C–C bond between the 2(1H)-quinolinone moiety and the phenol moiety and between the 2(1H)-quinolinone moiety and the 1H-indole moiety, respectively. Compound 3 possesses an unusual carbon skeleton and its putative biosynthetic pathway was discussed, and Compound 23 was deduced as a new indole alkaloid glycoside. Compounds 4–7 were identified as four new natural products by extensive spectroscopic experiments. Additionally, the anti-inflammatory activity was assessed based on nitric oxide (NO) production using Lipopolysaccharide-stimulated RAW264.7 macrophages. Compounds 9, 15, and 17 showed inhibitory effects with IC50 values of 1.2, 5.0, and 74.4 μM. View Full-Text
Keywords: Isatis tinctoria roots; alkaloids; structure identification; anti-inflammatory activity Isatis tinctoria roots; alkaloids; structure identification; anti-inflammatory activity
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MDPI and ACS Style

Zhang, D.; Shi, Y.; Li, J.; Ruan, D.; Jia, Q.; Zhu, W.; Chen, K.; Li, Y.; Wang, R. Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria. Molecules 2019, 24, 4033.

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