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Volume 24
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10.3390/molecules24224015
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Article

Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity

by
Zhaocui Sun
1,
Xudong Xu
1,
Hanqiao Liang
2,
Xinyi Xia
1,
Guoxu Ma
1,* and
Leiling Shi
3,*
1
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
2
Department of Biomedicine, Beijing City University, Beijing 100094, China
3
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(22), 4015; https://doi.org/10.3390/molecules24224015
Submission received: 21 September 2019 / Revised: 31 October 2019 / Accepted: 4 November 2019 / Published: 6 November 2019
(This article belongs to the Special Issue Cytotoxic Activity of Plant Extracts)
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Abstract

Five new meroterpenoids, clavipols A–B (1–2) with a 12-membered ether ring and clavilactones G–I (3–5) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete Clitocybe clavipes. Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of 1 was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds (1–5) were tested for their cytotoxic activity against three human tumor cell lines (Hela, SGC-7901, and SHG-44) in vitro after treatment for 48 h. Compound 4 exhibited moderate cytotoxic activity against Hela and SGC-7901 tumor cell lines, with IC50 values of 23.5 and 14.5 µM, respectively.
Keywords: meroterpenoids; Clitocybe clavipes; basidiomycete; cytotoxicity meroterpenoids; Clitocybe clavipes; basidiomycete; cytotoxicity

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MDPI and ACS Style

Sun, Z.; Xu, X.; Liang, H.; Xia, X.; Ma, G.; Shi, L. Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity. Molecules 2019, 24, 4015. https://doi.org/10.3390/molecules24224015

AMA Style

Sun Z, Xu X, Liang H, Xia X, Ma G, Shi L. Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity. Molecules. 2019; 24(22):4015. https://doi.org/10.3390/molecules24224015

Chicago/Turabian Style

Sun, Zhaocui, Xudong Xu, Hanqiao Liang, Xinyi Xia, Guoxu Ma, and Leiling Shi. 2019. "Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity" Molecules 24, no. 22: 4015. https://doi.org/10.3390/molecules24224015

APA Style

Sun, Z., Xu, X., Liang, H., Xia, X., Ma, G., & Shi, L. (2019). Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity. Molecules, 24(22), 4015. https://doi.org/10.3390/molecules24224015

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