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Open AccessArticle

Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Polygonum capitatum Extract

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State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, 4 Beijing Road, Guiyang 550004, China
2
School of Pharmacy, Guizhou Medical University, 4 Beijing Road, Guiyang 550004, China
3
Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, 4 Beijing Road, Guiyang 550004, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Young G. Shin and Jianbo Xiao
Molecules 2019, 24(21), 3873; https://doi.org/10.3390/molecules24213873
Received: 31 August 2019 / Revised: 28 September 2019 / Accepted: 24 October 2019 / Published: 27 October 2019
Polygonum capitatum Buch.-Ham. ex D. Don is traditionally used by Hmong for the treatment of urinary tract infections and pyelonephritis. Information regarding the pharmacokinetic behavior of the extract in the condition of pyelonephritis is lacking. In the present study, we aimed to compare the pharmacokinetic properties of gallic acid (GA), protocatechuic acid (PCA), and quercitrin (QR)—the main bioactive constituents in the herb—in normal and pyelonephritis rats. The plasma samples were collected at various time points after administration of a single dose of Polygonum capitatum extract. The plasma level of GA, PCA, and QR at the designed time points was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and drug concentration versus time plots were constructed to estimate the pharmacokinetic parameters. The AUC(0-t), AUC(0-∞), MRT(0-t), and CL of GA, PCA, and QR in pyelonephritis rats was significantly different from those of the normal rats. The results indicated that the three constituents have higher rate of uptake and slower rate of elimination in the rats with pyelonephritis, suggesting altered rate and extent of drug metabolism. View Full-Text
Keywords: gallic acid; pharmacokinetics; Polygonum capitatum extract; protocatechuic acid; pyelonephritis; quercitrin; UPLC-MS/MS gallic acid; pharmacokinetics; Polygonum capitatum extract; protocatechuic acid; pyelonephritis; quercitrin; UPLC-MS/MS
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MDPI and ACS Style

Huang, Y.; Zhou, Z.; Yang, W.; Gong, Z.; Li, Y.; Chen, S.; Wang, Y.; Wang, A.; Lan, Y.; Liu, T.; Zheng, L. Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Polygonum capitatum Extract. Molecules 2019, 24, 3873. https://doi.org/10.3390/molecules24213873

AMA Style

Huang Y, Zhou Z, Yang W, Gong Z, Li Y, Chen S, Wang Y, Wang A, Lan Y, Liu T, Zheng L. Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Polygonum capitatum Extract. Molecules. 2019; 24(21):3873. https://doi.org/10.3390/molecules24213873

Chicago/Turabian Style

Huang, Yong; Zhou, Zuying; Yang, Wu; Gong, Zipeng; Li, Yueting; Chen, Siying; Wang, Yonglin; Wang, Aimin; Lan, Yanyu; Liu, Ting; Zheng, Lin. 2019. "Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Polygonum capitatum Extract" Molecules 24, no. 21: 3873. https://doi.org/10.3390/molecules24213873

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