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Open AccessArticle

Supercritical Carbon Dioxide (scCO2) Extraction of Phenolic Compounds from Lavender (Lavandula angustifolia) Flowers: A Box-Behnken Experimental Optimization

Supercritical Extraction Department, Sieć Badawcza Łukasiewicz - Instytut Nowych Syntez Chemicznych, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland
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Academic Editors: Robert Shellie and Francesco Cacciola
Molecules 2019, 24(18), 3354; https://doi.org/10.3390/molecules24183354
Received: 17 August 2019 / Revised: 13 September 2019 / Accepted: 13 September 2019 / Published: 15 September 2019
(This article belongs to the Special Issue Recent Advances in Food and Natural Product Analysis)
Due to their numerous health benefits associated with various diseases and anti-oxidation properties, the phenolic compounds collectively referred to as phytochemicals have attracted a lot of interest, however, a single extraction method for polyphenols has not been developed yet. Supercritical fluid extraction, a green extraction method, provides the final product without organic solvent residues. In this work the extraction of lavender was performed using supercritical carbon dioxide. A statistical experimental design based on the Box-Behnken (B-B) method was planned, and the extraction yields and total phenolic contents were measured for three different variables: pressure, temperature and extraction time. The ranges were 200–300 bar, 40–60 °C and 15–45 min. The extracts yields from scCO2 extraction were in the range of 4.3–9.2 wt.%. The highest yield (9.2 wt.%) was achieved at a temperature of 60 °C under the pressure of 250 bar after 45 min. It also corresponded to the highest total phenolic content (10.17 mg GAE/g extract). Based on the study, the statistically generated optimal extraction conditions to obtain the highest total phenolic compounds concentration from flowers of Lavandula angustifolia were a temperature of 54.5 °C, pressure of 297.9 bar, and the time of 45 min. Based on the scavenging activity percentage (AA%) of scCO2 extracts, it is concluded that the increase of extraction pressure had a positive influence on the increase of AA% values. View Full-Text
Keywords: lavender; optimization; phenolic compounds; supercritical fluid extraction; total phenolic content lavender; optimization; phenolic compounds; supercritical fluid extraction; total phenolic content
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Tyśkiewicz, K.; Konkol, M.; Rój, E. Supercritical Carbon Dioxide (scCO2) Extraction of Phenolic Compounds from Lavender (Lavandula angustifolia) Flowers: A Box-Behnken Experimental Optimization. Molecules 2019, 24, 3354.

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