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Chemical and Biocatalytic Routes to Arbutin

by 1,‡, 1,‡, 1,* and 2,3,*
State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan 430062, China
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim, Germany
Chemistry Department, Philipps-University, Hans-Meerwein-Str. 4, 35032 Marburg, Germany
Authors to whom correspondence should be addressed.
Dedicated to Professor Dieter Schinzer on the occasion of his 65th birthday.
These authors contributed equally to this work.
Molecules 2019, 24(18), 3303;
Received: 3 August 2019 / Revised: 4 September 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
Arbutin (also called β-arbutin) is a natural product occurring in the leaves of a variety of different plants, the bearberries of the Ericaceae and Saxifragaceae families being prominent examples. It is a β-glucoside derived from hydroquinone (HQ; 1,4-dihydroxybenzene). Arbutin has been identified in traditional Chinese folk medicines as having, inter alia, anti-microbial, anti-oxidant, and anti-inflammatory properties that useful in the treatment of different ailments including urinary diseases. Today, it is also used worldwide for the treatment of skin ailments by way of depigmenting, which means that arbutin is a component of many products in the cosmetics and healthcare industries. It is also relevant in the food industry. Hundreds of publications have appeared describing the isolation, structure determination, toxicology, synthesis, and biological properties of arbutin as well as the molecular mechanism of melanogenesis (tyrosinase inhibition). This review covers the most important aspects with special emphasis on the chemical and biocatalytic methods for the production of arbutin. View Full-Text
Keywords: arbutin; glycosyltransferases; glucosides; shikimate pathway; cosmetics; directed evolution; Chinese folk medicines arbutin; glycosyltransferases; glucosides; shikimate pathway; cosmetics; directed evolution; Chinese folk medicines
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MDPI and ACS Style

Zhou, H.; Zhao, J.; Li, A.; Reetz, M.T. Chemical and Biocatalytic Routes to Arbutin . Molecules 2019, 24, 3303.

AMA Style

Zhou H, Zhao J, Li A, Reetz MT. Chemical and Biocatalytic Routes to Arbutin . Molecules. 2019; 24(18):3303.

Chicago/Turabian Style

Zhou, Hangyu, Jing Zhao, Aitao Li, and Manfred T. Reetz. 2019. "Chemical and Biocatalytic Routes to Arbutin " Molecules 24, no. 18: 3303.

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