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Open AccessFeature PaperArticle

Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis

1
Leibniz Institute of Photonic Technology, 07745 Jena, Germany
2
Friedrich Schiller University, Institute of Physical Chemistry, 07745 Jena, Germany
3
Friedrich Schiller University, Abbe Centre of Photonics, 07745 Jena, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Academic Editors: Christian Huck and Krzysztof B. Bec
Molecules 2019, 24(18), 3229; https://doi.org/10.3390/molecules24183229
Received: 21 July 2019 / Revised: 31 August 2019 / Accepted: 2 September 2019 / Published: 5 September 2019
The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets. A very important issue is the identification of substandard tablets that do not contain the nominal amounts of the active pharmaceutical ingredient (API), and the differentiation between genuine products and products without any active ingredient or with a false active ingredient. This work presents a novel approach based on fiber-array based Raman hyperspectral imaging to qualify and quantify the antimalarial APIs lumefantrine and artemether directly and non-invasively in a tablet in a time-efficient way. The investigations were carried out with the antimalarial tablet Riamet® and self-made model tablets, which were used as examples of counterfeits and substandard. Partial least-squares regression modeling and density functional theory calculations were carried out for quantification of lumefantrine and artemether and for spectral band assignment. The most prominent differentiating vibrational signatures of the APIs were presented. View Full-Text
Keywords: Raman spectroscopy; hyperspectral imaging; analytical spectroscopy; counterfeit and substandard pharmaceuticals; DFT calculations; chemometrics; PLSR; API; lumefantrine; artemether; antimalarial tablets Raman spectroscopy; hyperspectral imaging; analytical spectroscopy; counterfeit and substandard pharmaceuticals; DFT calculations; chemometrics; PLSR; API; lumefantrine; artemether; antimalarial tablets
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Frosch, T.; Wyrwich, E.; Yan, D.; Domes, C.; Domes, R.; Popp, J.; Frosch, T. Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis. Molecules 2019, 24, 3229.

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