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Open AccessArticle

Osteopathic Manipulation Treatment Improves Cerebro–splanchnic Oximetry in Late Preterm Infants

Department, Italian Academy of Traditional Osteopathy (AIOT), 65100 Pescara, Italy
Laboratory Research, Department of Paediatric Cardiovascular Surgery, San Donato Milanese University Hospital, 20097 San Donato, Italy
Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children’s Hospital, 15121 Alessandria, Italy
Neonatal Intensive Care Unit G. D’Annunzio University of Chieti, 66100 Chieti, Italy
Author to whom correspondence should be addressed.
Academic Editors: Christian Huck and Krzysztof B. Bec
Molecules 2019, 24(18), 3221;
Received: 25 June 2019 / Revised: 22 August 2019 / Accepted: 27 August 2019 / Published: 4 September 2019
Background: To evaluate the effectiveness/side-effects of osteopathic manipulation treatment (OMT) performed on the 7th post-natal day, on cerebro–splanchnic oximetry, tissue activation and hemodynamic redistribution in late preterm (LP) infants by using near infrared spectroscopy (NIRS). Methods: Observational pretest-test study consisting in a cohort of 18 LPs who received OMT on the 7th post-natal day. NIRS monitoring was performed at three different time-points: 30 min before (T0), (30 min during (T1) and 30 min after OMT (T2). We evaluated the effects of OMT on the following NIRS parameters: cerebral (c), splanchnic (s) regional oximetry (rSO2), cerebro–splanchnic fractional tissue oxygen extraction (FTOE) and hemodynamic redistribution (CSOR). Results: crSO2 and cFTOE significantly (P < 0.001) improved at T0-T2; srSO2 significantly (P < 0.001) decreased and sFTOE increased at T0-T1. Furthermore, srSO2 and sFTOE significantly improved at T1-T2. Finally, CSOR significantly (P < 0.05) increased at T0-T2. Conclusions: The present data show that OMT enhances cerebro–splanchnic oximetry, tissue activation and hemodynamic redistribution in the absence of any adverse clinical or laboratory pattern. The results indicate the usefulness of further randomized studies in wider populations comparing the effectiveness of OMT with standard rehabilitation programs. View Full-Text
Keywords: NIRS; osteopathy; late preterm; brain; splanchnic NIRS; osteopathy; late preterm; brain; splanchnic
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Marinelli, B.; Pluchinotta, F.; Cozzolino, V.; Barlafante, G.; Strozzi, M.C.; Marinelli, E.; Franchini, S.; Gazzolo, D. Osteopathic Manipulation Treatment Improves Cerebro–splanchnic Oximetry in Late Preterm Infants. Molecules 2019, 24, 3221.

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