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Open AccessArticle

Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening

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Department of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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Department of Plastic and Reconstructive Surgery, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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Department of Botany, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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Department of Pathology, CFR Clinical Hospital, 13-15, Tudor Vladimirescu, 300173 Timisoara, Romania
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Department of Physical Chemistry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
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CBS Medcom Hospital, 12 Popa Sapca Street, 300047 Timisoara, Romania
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Department of Orthodontrics, Faculty of Dentistry, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timisoara, Romania
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(17), 3087; https://doi.org/10.3390/molecules24173087
Received: 15 July 2019 / Revised: 23 August 2019 / Accepted: 23 August 2019 / Published: 25 August 2019
(This article belongs to the Special Issue Antitumor and Anti-HIV Agents from Natural Products)
Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. absinthium L. as well as the biological potential (antioxidant activity, cytotoxic, anti-migratory and anti-inflammatory properties). Both plant materials showed quite similar thermogravimetric, FT-IR phenolic profile (high chlorogenic acid) with mild antioxidant capacity [ascorbic acid (0.02–0.1) > leaves (0.1–2.0) > stem (0.1–2.0)]. Alcoholic extracts from these plant materials showed a cytotoxic effect against A375 (melanoma) and MCF7 (breast adenocarcinoma) and affected less the non-malignant HaCaT cells (human keratinocytes) at 72 h post-stimulation and this same trend was observed in the anti-migratory (A375, MCF7 > HaCat) assay. Lastly, extracts ameliorated the pro-inflammatory effect of TPA (12-O-tetradecanoylphorbol-13-acetate) in mice ears, characterized by a diffuse neutrophil distribution with no exocytosis or micro-abscesses. View Full-Text
Keywords: Artemisia absinthium L.; antioxidants; total phenolic content; cytotoxicity; melanoma and breast cancer cell line; HaCaT cells; inflammation Artemisia absinthium L.; antioxidants; total phenolic content; cytotoxicity; melanoma and breast cancer cell line; HaCaT cells; inflammation
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Moacă, E.-A.; Pavel, I.Z.; Danciu, C.; Crăiniceanu, Z.; Minda, D.; Ardelean, F.; Antal, D.S.; Ghiulai, R.; Cioca, A.; Derban, M.; Simu, S.; Chioibaş, R.; Szuhanek, C.; Dehelean, C.-A. Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening. Molecules 2019, 24, 3087.

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