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Open AccessArticle

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway

1,2,†, 1,2,†, 1,2,†, 1,2, 1,2, 1,2, 1,2 and 1,2,*
1
Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
*
Author to whom correspondence should be addressed.
These authors contributed to the work equally.
Molecules 2019, 24(16), 2966; https://doi.org/10.3390/molecules24162966
Received: 9 June 2019 / Revised: 9 August 2019 / Accepted: 14 August 2019 / Published: 15 August 2019
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Abstract

Soy isoflavones (SIF) are biologically active compounds of non-steroidal and phenolic properties that are richly present in soybeans, which can reduce the body weight and blood lipids of obese animals. Recently, SIF have been reported to affect reproductive ability in obese male rats. However, the specific mechanism has not been well defined. The aim of the current study was to study the possible mechanisms for the effect of SIF administration on obesity induced spermatogenic defects. Obese rats model induced by high-fat diets were established and gavage treated with 0, 50,150 or 450 mg of SIF/kg body weight/day for 4 weeks. Here, our research shows that obesity resulted in spermatogenic degeneration, imbalance of reproductive hormone, testicular oxidative stress and germ cell apoptosis, whereas evidently recovery effects were observed at 150 and 450 mg/kg SIF. We also have discovered that 150 and 450 mg/kg SIF can activate Nrf2/HO-1 pathway in control of Bcl-2, BAX and cleaved caspase-3 expression with implications in antioxidant protection. Our study indicates the potential mechanism of SIF regulating spermatogenic function in obese rats, and provides a scientific experimental basis for the regulation of biological function of obese male reproductive system by SIF. View Full-Text
Keywords: soy isoflavones; obesity; spermatogenesis; oxidative stress; apoptosis soy isoflavones; obesity; spermatogenesis; oxidative stress; apoptosis
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Luo, Q.; Li, Y.; Huang, C.; Cheng, D.; Ma, W.; Xia, Y.; Liu, W.; Chen, Z. Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway. Molecules 2019, 24, 2966.

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