Next Article in Journal
The Profile of Secondary Metabolites and Other Bioactive Compounds in Cucurbita pepo L. and Cucurbita moschata Pumpkin Cultivars
Previous Article in Journal
Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening
Article Menu

Export Article

Open AccessArticle

The Radiation Sterilization of Ertapenem Sodium in the Solid State

Department of Pharmacognosy, Poznan University of Medical Sciences, Święcickiego 4, 60-781 Poznań, Poland
Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznań, Poland
Institute of Material Science and Engineering, Poznan University of Technology, Jana Pawła II 24, 60-965 Poznań, Poland
Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, Poland
Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland
Author to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Molecules 2019, 24(16), 2944;
Received: 22 July 2019 / Revised: 10 August 2019 / Accepted: 11 August 2019 / Published: 14 August 2019
PDF [2446 KB, uploaded 14 August 2019]


For the first time, the influence of ionising radiation on the physicochemical properties of ertapenem in solid state was studied. During our studies, we evaluated the possibility of applying radiosterilization to obtain sterile ertapenem. Spectroscopic (Fourier Transform Infrared (FT-IR)), thermal (differential scanning calorimetry (DSC), chromatography (High-Performance Liquid Chromatography (HPLC) and HPLC-MS), and X-ray powder diffraction (XRPD) studies shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of ertapenem irradiated with the dose of 25 kGy was only reduced for one species. Based on the received results, we can conclude that radiostelization is a promising alternative method of obtaining sterile ertapenem. In our studies, ertapenem was also exposed to e-beam radiation with a dose of 400 kGy. It was determined that two novel degradation products that are structurally differently to degradants formed during hydrolysis and thermolysis. View Full-Text
Keywords: ertapenem; radiation sterilization; Q-TOF; microbiological activity; FT-IR; HPLC; EPR; XRPD; Raman ertapenem; radiation sterilization; Q-TOF; microbiological activity; FT-IR; HPLC; EPR; XRPD; Raman

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kilińska, K.; Cielecka-Piontek, J.; Skibiński, R.; Szymanowska, D.; Miklaszewski, A.; Lewandowska, K.; Bednarski, W.; Mizera, M.; Tykarska, E.; Zalewski, P. The Radiation Sterilization of Ertapenem Sodium in the Solid State. Molecules 2019, 24, 2944.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top