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Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities

1
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China
3
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Molecules 2019, 24(16), 2937; https://doi.org/10.3390/molecules24162937
Received: 1 August 2019 / Revised: 11 August 2019 / Accepted: 13 August 2019 / Published: 13 August 2019
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Abstract

Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F–J (15), were obtained from the rhizomes of Hemsleya penxianensis (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC50 ranging from 2.25 to 49.44 µM in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC50 > 50 µM). Compound 5 showed the most significant cytotoxic activity with the IC50 value of 2.25, 4.72, and 5.33 µM in 48 h, respectively. View Full-Text
Keywords: Hemsleya penxianensis; cucurbitane-typetriterpenoid glycosides; cytotoxicity Hemsleya penxianensis; cucurbitane-typetriterpenoid glycosides; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, D.-L.; Xu, X.-D.; Li, R.-T.; Wang, B.-W.; Yu, M.; Liu, Y.-Y.; Ma, G.-X. Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities. Molecules 2019, 24, 2937.

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