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Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

Research Center of CHU de Québec, CUO-Recherche and Université Laval, Faculty of Medicine, Ophthalmology Department, chemin Ste-Foy 1050, G1S 4L8, Québec (Québec), Canada
Author to whom correspondence should be addressed.
Academic Editors: Paola Luciani and Davide Brambilla
Molecules 2019, 24(16), 2929;
Received: 28 June 2019 / Revised: 1 August 2019 / Accepted: 8 August 2019 / Published: 13 August 2019
PDF [4719 KB, uploaded 13 August 2019]
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Nanotechnologies are increasingly being developed for medical purposes. However, these nanomaterials require ultrastability for better control of their pharmacokinetics. The present study describes three types of ultrastable gold nanoparticles stabilized by thiolated polyethylene glycol groups remaining intact when subjected to some of the harshest conditions described thus far in the literature, such as autoclave sterilization, heat and freeze-drying cycles, salts exposure, and ultracentrifugation. Their stability is characterized by transmission electron microscopy, UV-visible spectroscopy, and dynamic light scattering. For comparison purposes, two conventional nanoparticle types were used to assess their colloidal stability under all conditions. The ability of ultrastable gold nanoparticles to encapsulate bimatoprost, a drug for glaucoma treatment, is demonstrated. MTS assays on human corneal epithelial cells is assessed without changing cell viability. The impact of ultrastable gold nanoparticles on wound healing dynamics is assessed on tissue engineered corneas. These results highlight the potential of ultrastable gold nanoparticles as a drug delivery system in ocular therapy. View Full-Text
Keywords: ultrastability; gold nanoparticles; drug delivery; MTS assay; wound healing assay ultrastability; gold nanoparticles; drug delivery; MTS assay; wound healing assay

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Masse, F.; Desjardins, P.; Ouellette, M.; Couture, C.; Omar, M.M.; Pernet, V.; Guérin, S.; Boisselier, E. Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System. Molecules 2019, 24, 2929.

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