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Open AccessArticle

Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats

1
Scientific Research and Experiment Center, Henan University of Chinese Medicine, Zhengzhou 450046, China
2
Department of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
3
Graduate School, Henan University of Chinese Medicine, Zhengzhou 450046, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Chingfeng Weng
Molecules 2019, 24(16), 2887; https://doi.org/10.3390/molecules24162887
Received: 30 June 2019 / Revised: 6 August 2019 / Accepted: 6 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue The Potential Use of Herbal Medicinal Products in Chronic Disorders)
The present study was envisaged to investigate the chemical constituents and the intervention effects of Portulaca oleracea extract (POE) on acute alcoholic liver injury of rats. The chemical composition of POE was detected by high performance liquid chromatography (HPLC). Sixty male Wistar rats were divided into 6 groups: Normal control (NC) group, acute alcoholic liver injury model group (ALI), low, medium and high dose of POE (25, 50, 100 mg/kg) groups and bifendate (BF, 3.75 mg/kg) group. Each group was given by intragastrical administration for 7 days. Alcoholic liver injury was induced in the experimental model by administering 50% ethanol at 8 mL/kg and repeated administration after 6 h, for a period of 7 days. The results showed that pretreatment with POE significantly reduced the ethanol-elevated serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and triglyceride (TG). The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in liver were enhanced followed by administration of POE, while the content of nitric oxide (NO) and malondialdehyde (MDA) was found to decrease. Hepatic content of tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) was also reduced by POE treatment. These results indicated that POE could increase the antioxidant capacity and relieve the inflammatory injury of the liver cells induced by ethanol. Meanwhile, in our study, POE reduced the expression of miR-122, acetyl coenzyme A carboxylase (ACC) 1 mRNA and protein and increased the expression of lipoprotein lipase (LPL) mRNA and protein in liver, which indicated that POE could improve the lipid metabolism disorder induced by ethanol. Our findings suggested that POE had protective effects on acute alcoholic liver injury of rats. View Full-Text
Keywords: Portulaca oleracea extract (POE); acute alcoholic liver injury; oxidative stress; inflammatory reaction; lipid metabolism; miR-122 Portulaca oleracea extract (POE); acute alcoholic liver injury; oxidative stress; inflammatory reaction; lipid metabolism; miR-122
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Qiao, J.-Y.; Li, H.-W.; Liu, F.-G.; Li, Y.-C.; Tian, S.; Cao, L.-H.; Hu, K.; Wu, X.-X.; Miao, M.-S. Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats. Molecules 2019, 24, 2887.

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