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Open AccessArticle

Antifungal Effect of Magnolol and Honokiol from Magnolia officinalis on Alternaria alternata Causing Tobacco Brown Spot

1
College of Plant Protection and State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China
2
College of agriculture, Inner Mongolia Agricultural University, Huhhot 010018, China
3
Microbial Resources of Research Center, Microbiology Institute of Shaanxi, Xian 710043, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Molecules 2019, 24(11), 2140; https://doi.org/10.3390/molecules24112140
Received: 5 May 2019 / Revised: 29 May 2019 / Accepted: 30 May 2019 / Published: 6 June 2019
In this study, two phenol compounds, magnolol and honokiol, were extracted from Magnolia officinalis and identified by LC-MS, 1H- and 13C-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including Alternaria alternata (Fr.) Keissl, Penicillium expansum (Link) Thom, Alternaria dauci f.sp. solani, Fusarium moniliforme J. Sheld, Fusarium oxysporum Schltdl., Valsa mali Miyabe & G. Yamada, and Rhizoctonia solani J.G. Kühn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and honokiol. The results showed that they inhibited the growth of A. alternata in a dose-dependent manner. Moreover, magnolol and honokiol treatment resulted in distorted mycelia and increased the cell membrane permeability of A. alternata, as determined by conductivity measurements. These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases. View Full-Text
Keywords: Magnolia officinalis; magnolol; honokiol; antifungal activity; Alternaria alternata Magnolia officinalis; magnolol; honokiol; antifungal activity; Alternaria alternata
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Chen, Y.-H.; Lu, M.-H.; Guo, D.-S.; Zhai, Y.-Y.; Miao, D.; Yue, J.-Y.; Yuan, C.-H.; Zhao, M.-M.; An, D.-R. Antifungal Effect of Magnolol and Honokiol from Magnolia officinalis on Alternaria alternata Causing Tobacco Brown Spot. Molecules 2019, 24, 2140.

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