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Open AccessReview

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

1
Department of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, 23, Ghe. Marinescu Street, 400337 Cluj-Napoca, Romania
2
Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, CaleaMănăştur 3-5, 400372 Cluj-Napoca, Romania
3
Laboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(11), 2046; https://doi.org/10.3390/molecules24112046
Received: 13 April 2019 / Revised: 20 May 2019 / Accepted: 22 May 2019 / Published: 29 May 2019
(This article belongs to the Special Issue Natural Product Pharmacology and Medicinal Chemistry)
Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of which can be found in spontaneous flora. The chemical composition of the leaves revealed three major phenolic compounds: chlorogenic acid, quercetin and arbutin. The health promoting functions of these compounds, such as antioxidant and anti-inflammatory properties that could have preventive effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity, have been exemplified by both in vitro and in vivo studies in this review. Furthermore, the importance of bioaccessibility and bioavailability of the phenolic compounds have been summarized. The findings highlight the fact that leaves of some Ericaceae species deserve increased attention and should be studied more profoundly for their biological activities, especially those from spontaneous flora. View Full-Text
Keywords: Ericaceae; Vaccinium spp. leaves; phenolic components; arbutin; chlorogenic acid; quercetin Ericaceae; Vaccinium spp. leaves; phenolic components; arbutin; chlorogenic acid; quercetin
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MDPI and ACS Style

Ștefănescu, B.E.; Szabo, K.; Mocan, A.; Crişan, G. Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits. Molecules 2019, 24, 2046. https://doi.org/10.3390/molecules24112046

AMA Style

Ștefănescu BE, Szabo K, Mocan A, Crişan G. Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits. Molecules. 2019; 24(11):2046. https://doi.org/10.3390/molecules24112046

Chicago/Turabian Style

Ștefănescu, Bianca E.; Szabo, Katalin; Mocan, Andrei; Crişan, Gianina. 2019. "Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits" Molecules 24, no. 11: 2046. https://doi.org/10.3390/molecules24112046

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