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Open AccessArticle

Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance

School of Life Sciences, Northeast Normal University, Jilin 130024, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Atanas G. Atanasov, Karel Šmejkal and Elke Heiss
Molecules 2019, 24(1), 46; https://doi.org/10.3390/molecules24010046
Received: 9 November 2018 / Revised: 15 December 2018 / Accepted: 19 December 2018 / Published: 22 December 2018
(This article belongs to the Special Issue Bioactive Molecules and Their Mechanisms of Action)
Despite the edible fungus Amillariella mellea possessing a variety of biological activities, its effects on diabetes are still unclear. Polysaccharides are the main bioactive ingredients. In order to destroy the cell wall to obtain more polysaccharides, we used NaOH solution to extract Amillariella mellea fruiting bodies. The alkali extraction (AAMP) was identified as a polysaccharide-enriched fraction. Using type 2 diabetic rats induced by co-treatment of a high fat diet (HFD) and dexamethasone (DEX), we evaluated the hypoglycemic effects of AAMP. The results showed that oral administration of a high dose of AAMP markedly lowered fasting blood glucose, improving glucose intolerance and insulin resistance. AAMP also enhanced the level of LPL and the expressions of two critical lipases ATGL and HSL, leading to a decrease of serum triglyceride. In addition, AAMP specifically suppressed the expression of SREBP-1c, resulting in AAMP observably inhibiting lipid accumulation in the liver. These findings demonstrated that the improvement of AAMP on HFD/DEX-induced insulin resistance was correlated with its regulation of lipid metabolism. Our results indicated that AAMP could be a novel natural drug or health food used for the treatment of diabetes. View Full-Text
Keywords: Amillariella mellea; polysaccharide; insulin resistance; lipid metabolism Amillariella mellea; polysaccharide; insulin resistance; lipid metabolism
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Yang, S.; Meng, Y.; Yan, J.; Wang, N.; Xue, Z.; Zhang, H.; Fan, Y. Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance. Molecules 2019, 24, 46.

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