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Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

1
Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA
2
Global Research IT, Merck & Co., Inc., Boston, MA 02210, USA
3
Department of Chemical and Biological Engineering, the University of Alabama, Tuscaloosa, AL 35487, USA
4
Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Jianxun Ding, Yang Li and Mingqiang Li
Molecules 2019, 24(1), 4; https://doi.org/10.3390/molecules24010004
Received: 21 November 2018 / Revised: 14 December 2018 / Accepted: 17 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Smart and Functional Polymers)
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PDF [6520 KB, uploaded 20 December 2018]
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Abstract

Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. This review article aims to provide general guidelines for the rational design of more effective pH-responsive nanomaterials for cancer diagnosis and treatment. View Full-Text
Keywords: pH responsive polymers; nanomedicine; tumor imaging; drug delivery pH responsive polymers; nanomedicine; tumor imaging; drug delivery
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Tang, H.; Zhao, W.; Yu, J.; Li, Y.; Zhao, C. Recent Development of pH-Responsive Polymers for Cancer Nanomedicine. Molecules 2019, 24, 4.

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