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Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA
Global Research IT, Merck & Co., Inc., Boston, MA 02210, USA
Department of Chemical and Biological Engineering, the University of Alabama, Tuscaloosa, AL 35487, USA
Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Authors to whom correspondence should be addressed.
Academic Editors: Jianxun Ding, Yang Li and Mingqiang Li
Molecules 2019, 24(1), 4;
Received: 21 November 2018 / Revised: 14 December 2018 / Accepted: 17 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Smart and Functional Polymers)
PDF [6520 KB, uploaded 20 December 2018]
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Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. This review article aims to provide general guidelines for the rational design of more effective pH-responsive nanomaterials for cancer diagnosis and treatment. View Full-Text
Keywords: pH responsive polymers; nanomedicine; tumor imaging; drug delivery pH responsive polymers; nanomedicine; tumor imaging; drug delivery

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Tang, H.; Zhao, W.; Yu, J.; Li, Y.; Zhao, C. Recent Development of pH-Responsive Polymers for Cancer Nanomedicine. Molecules 2019, 24, 4.

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