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Open AccessReview

Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

1
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan
2
Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8501, Japan
3
Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
4
Jyoto Hospital, 11-22 Hanatenhigashi 2-chome, Tsurumi-ku Osaka-shi, Osaka 538-0044, Japan
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(9), 2357; https://doi.org/10.3390/molecules23092357
Received: 30 July 2018 / Revised: 10 September 2018 / Accepted: 13 September 2018 / Published: 14 September 2018
(This article belongs to the Special Issue Catechin in Human Health and Disease)
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders worldwide. Its incidence is gradually increasing because of an aging demographic. Therefore, AD prevention and modification is important to improve the health status of older adults. Oxidative stress is a component of the pathological mechanisms underlying AD. It is caused by a disruption of the balance between reactive oxygen species and antioxidant molecules. This imbalance also causes neuroinflammation. Catechins, which are bioactive components of tea, have antioxidative and anti-inflammatory effects. Moreover, other potential properties related to AD prevention and modification have been reported in in vitro and in vivo studies. Several clinical studies have also been conducted to date. The current review summarizes recent updates and perspectives of the effects of catechins on AD based on the molecular mechanisms and related clinical studies. View Full-Text
Keywords: Alzheimer’s disease; catechin; molecular mechanisms; clinical study Alzheimer’s disease; catechin; molecular mechanisms; clinical study
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MDPI and ACS Style

Ide, K.; Matsuoka, N.; Yamada, H.; Furushima, D.; Kawakami, K. Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives. Molecules 2018, 23, 2357. https://doi.org/10.3390/molecules23092357

AMA Style

Ide K, Matsuoka N, Yamada H, Furushima D, Kawakami K. Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives. Molecules. 2018; 23(9):2357. https://doi.org/10.3390/molecules23092357

Chicago/Turabian Style

Ide, Kazuki; Matsuoka, Norihiro; Yamada, Hiroshi; Furushima, Daisuke; Kawakami, Koji. 2018. "Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives" Molecules 23, no. 9: 2357. https://doi.org/10.3390/molecules23092357

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