Next Article in Journal
Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line
Next Article in Special Issue
Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance
Previous Article in Journal
Glycosaminoglycan-Protein Interactions by Nuclear Magnetic Resonance (NMR) Spectroscopy
Previous Article in Special Issue
Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Molecules 2018, 23(9), 2316;

Recent Advances in Mitochondria-Targeted Gene Delivery

Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, Korea
Institute of Advanced Materials and Systems, Sookmyung Women’s University, Seoul 04310, Korea
Research Institute of ICT Convergence, Sookmyung Women’s University, Seoul 04310, Korea
Author to whom correspondence should be addressed.
Received: 24 August 2018 / Revised: 6 September 2018 / Accepted: 8 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Gene Delivery)
Full-Text   |   PDF [2266 KB, uploaded 14 September 2018]   |  


Mitochondria are the energy-producing organelles of cells. Mitochondrial dysfunctions link to various syndromes and diseases including myoclonic epilepsy and ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial diseases often result from mutations of mitochondrial genomes and nuclear genes that encode the mitochondrial components. However, complete intracellular correction of the mutated genetic parts relevant to mitochondrial structures and functions is technically challenging. Instead, there have been diverse attempts to provide corrected genetic materials with cells. In this review, we discuss recent novel physical, chemical and biological strategies, and methods to introduce genetic cargos into mitochondria of eukaryotic cells. Effective mitochondria-targeting gene delivery systems can reverse multiple mitochondrial disorders by enabling cells to produce functional mitochondrial components. View Full-Text
Keywords: mitochondrial gene delivery; mitochondrial disease; mitochondrial genomes; heteroplasmy; mitochondrial matrix mitochondrial gene delivery; mitochondrial disease; mitochondrial genomes; heteroplasmy; mitochondrial matrix

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Jang, Y.-H.; Lim, K.-I. Recent Advances in Mitochondria-Targeted Gene Delivery. Molecules 2018, 23, 2316.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top