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Molecules 2018, 23(9), 2247;

Silicon Dioxide Nanoparticles Enhance Endotoxin-Induced Lung Injury in Mice

College of Veterinary Medicine (BK21 Plus Project Team), Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea
Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea
Herbal Medicinal Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 30 August 2018 / Accepted: 31 August 2018 / Published: 3 September 2018
(This article belongs to the Section Nanochemistry)
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Silicon dioxide nanoparticles (SiONPs), which are metal oxide nanoparticles, have been used in a wide variety of applications. In this study, acute pulmonary responses were examined after the intranasal instillation of SiONPs in mice primed with or without lipopolysaccharide (LPS, intranasal, 5 µg/mouse). The exposure to SiONPs increased the inflammatory cell counts and proinflammatory cytokines in the bronchoalveolar lavage fluid. SiONPs induced airway inflammation with increases in the phosphorylation of mitogen-activated protein kinases (MAPKs). The ratios of the inflammatory responses induced by the SiONPs were increased in the acute pulmonary disease model primed by LPS. Taken together, SiONPs exhibited toxicity to the respiratory system, which was associated with MAPK phosphorylation. In addition, the exposure to SiONPs exacerbated any existing inflammatory pulmonary diseases. These data showed the additive, as well as synergistic, interaction effects of SiONPs and LPS. We conclude that the exposure to SiONPs causes potential toxicity in humans, especially those with respiratory diseases. View Full-Text
Keywords: silicon dioxide nanoparticles; respiratory tract; inflammation; mitogen-activated protein kinase silicon dioxide nanoparticles; respiratory tract; inflammation; mitogen-activated protein kinase

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Ko, J.-W.; Lee, H.-J.; Shin, N.-R.; Seo, Y.-S.; Kim, S.-H.; Shin, I.-S.; Kim, J.-S. Silicon Dioxide Nanoparticles Enhance Endotoxin-Induced Lung Injury in Mice. Molecules 2018, 23, 2247.

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