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Open AccessFeature PaperArticle

Chemical Constituents and Antidepressant-Like Effects in Ovariectomized Mice of the Ethanol Extract of Alternanthera philoxeroides

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Graduate School of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
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Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
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ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
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Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Lexões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal
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Department of Chemistry, University of Leicester, University Road, Leicester LE 7 RH, UK
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Departamento de Química & QOPNA, Universidade de Aveiro, 3810-193 Aveiro, Portugal
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Department of Food Engineering, Faculty of Architecture and Engineering, Kilis 7 Aralık University, Kilis 79000, Turkey
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Authors to whom correspondence should be addressed.
Molecules 2018, 23(9), 2202; https://doi.org/10.3390/molecules23092202
Received: 22 August 2018 / Revised: 28 August 2018 / Accepted: 29 August 2018 / Published: 31 August 2018
(This article belongs to the Section Natural Products Chemistry)
The previously unreported flavone glycoside, demethyltorosaflavone B (2) and the E-propenoic acid substituted flavone, torosaflavone E (3a), were isolated together with nine previously reported metabolites, including indole-3-carbaldehyde, oleanonic acid, vanillic acid, p-hydroxybenzoic acid, altheranthin (1a), alternanthin B (1b), demethyltorosaflavone D (3b), luteolin 8-C-E-propenoic acid (4) and chrysoeriol 7-O-rhamnoside (5), from the ethanol extract of the aerial part of Althernanthera philoxeroides. The crude ethanol extract was evaluated for its in vitro estrogenic activity in MCF-7 breast cancer cell line. The crude ethanol extract was also investigated in vivo for its antidepressant-like effects on ovariectomized mice using tail suspension and forced swimming tests, while its effect on the locomotor activity was evaluated by a Y-maze test. The effect of the crude extract on the serum corticosterone level, size and volume of uterus of the ovariectomized mice were also investigated. The expression of the mouse cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF) and β-actin mRNAs in hippocampus and frontal cortex was also evaluated, using semiquantitative reverse transcription-polymerase chain reaction. The crude extract and the isolated compounds 1a, 1b, 3a, 3b and 5, were evaluated for their inhibitory effects on monoamine oxidases (MAOs)-A and -B. View Full-Text
Keywords: Althernanthera philoxeroides; estrogenic activity; antidepressant-like effects; MAO inhibitor; ovariectomized mice; C-glycosylated flavones; C-E-propenoic substituted flavones Althernanthera philoxeroides; estrogenic activity; antidepressant-like effects; MAO inhibitor; ovariectomized mice; C-glycosylated flavones; C-E-propenoic substituted flavones
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MDPI and ACS Style

Khamphukdee, C.; Monthakantirat, O.; Chulikhit, Y.; Buttachon, S.; Lee, M.; Silva, A.M.S.; Sekeroglu, N.; Kijjoa, A. Chemical Constituents and Antidepressant-Like Effects in Ovariectomized Mice of the Ethanol Extract of Alternanthera philoxeroides. Molecules 2018, 23, 2202.

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