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Molecules 2018, 23(9), 2111; https://doi.org/10.3390/molecules23092111

New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs

1
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 25 July 2018 / Revised: 14 August 2018 / Accepted: 19 August 2018 / Published: 22 August 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Five new naphthalene derivatives, named Eleutherols A–C (13) and Eleuthinones B–C (4,5), together with three known compounds were isolated from the bulbs of Eleutherine americana. Their structures were elucidated on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR techniques. These compounds exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro. View Full-Text
Keywords: Eleutherine americana; naphthalene derivatives; HUVECs Eleutherine americana; naphthalene derivatives; HUVECs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, D.-L.; Hu, M.-G.; Liu, Y.-Y.; Li, R.-T.; Yu, M.; Xu, X.-D.; Ma, G.-X. New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs. Molecules 2018, 23, 2111.

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