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Open AccessArticle

Bioactive Constituents from the Aerial Parts of Pluchea indica Less

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Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
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Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
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Authors to whom correspondence should be addressed.
Molecules 2018, 23(9), 2104; https://doi.org/10.3390/molecules23092104
Received: 8 August 2018 / Revised: 15 August 2018 / Accepted: 21 August 2018 / Published: 21 August 2018
Four new thiophenes, (3′′R)-pluthiophenol (1), (3′′R)-pluthiophenol-4′′-acetate (2), 3′′-ethoxy-(3′′S)-pluthiophenol (3), 3′′-ethoxy-(3′′S)-pluthiophenol-4′′-acetate (4), together with twenty-five known compounds were obtained from the 70% ethanol-water extract of the aerial parts of Pluchea indica Less. Their structures were elucidated by spectroscopic methods. Among the known isolates, compounds 7, 8, 11, 14, 15, 18, 20, 23, 2527 were isolated from Asteraceae family firstly, while compounds 6, 9, 10, 12, 13, 16, 19, 21, 28 were isolated from Pluchea genus for the first time. Meanwhile, compounds 1, 2, 10, 13, 18, 23 displayed significant inhibitory activities on LPS-induced NO production at 40 µM from RAW 264.7 macrophages, while compounds 3, 4, 2629 possessed moderate inhibitory effects. View Full-Text
Keywords: Pluchea indica Less.; chemical compositions; RAW 264.7 cells; anti-inflammatory activities Pluchea indica Less.; chemical compositions; RAW 264.7 cells; anti-inflammatory activities
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Ruan, J.; Li, Z.; Yan, J.; Huang, P.; Yu, H.; Han, L.; Zhang, Y.; Wang, T. Bioactive Constituents from the Aerial Parts of Pluchea indica Less. Molecules 2018, 23, 2104.

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