Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde Po.Box 812, Cameroon
Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan
Nutrition and Dietetics Department, School of Pharmacy, University of Concepción, Concepción 4070386, VIII–Bio Bio Region, Chile
Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade 11129, Serbia
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto–Portugal, Porto 4200-135, Portugal
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 30 June 2018 / Revised: 12 July 2018 / Accepted: 14 July 2018 / Published: 17 July 2018
In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori
activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.
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Sharifi-Rad, M.; Fokou, P.V.T.; Sharopov, F.; Martorell, M.; Ademiluyi, A.O.; Rajkovic, J.; Salehi, B.; Martins, N.; Iriti, M.; Sharifi-Rad, J. Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion. Molecules 2018, 23, 1751.
Sharifi-Rad M, Fokou PVT, Sharopov F, Martorell M, Ademiluyi AO, Rajkovic J, Salehi B, Martins N, Iriti M, Sharifi-Rad J. Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion. Molecules. 2018; 23(7):1751.
Sharifi-Rad, Mehdi; Fokou, Patrick V.T.; Sharopov, Farukh; Martorell, Miquel; Ademiluyi, Adedayo O.; Rajkovic, Jovana; Salehi, Bahare; Martins, Natália; Iriti, Marcello; Sharifi-Rad, Javad. 2018. "Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion." Molecules 23, no. 7: 1751.
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