Molecules 2018, 23(7), 1751; https://doi.org/10.3390/molecules23071751
Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion
Mehdi Sharifi-Rad 1, Patrick Valere Tsouh Fokou 2
, Farukh Sharopov 3, Miquel Martorell 4, Adedayo Oluwaseun Ademiluyi 5, Jovana Rajkovic 6, Bahare Salehi 7,8,*
, Natália Martins 9,10,*
, Marcello Iriti 11,*
and Javad Sharifi-Rad 12,13,*
, Farukh Sharopov 3, Miquel Martorell 4, Adedayo Oluwaseun Ademiluyi 5, Jovana Rajkovic 6, Bahare Salehi 7,8,*
, Natália Martins 9,10,*
, Marcello Iriti 11,*
and Javad Sharifi-Rad 12,13,*
1
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
2
Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde Po.Box 812, Cameroon
3
Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan
4
Nutrition and Dietetics Department, School of Pharmacy, University of Concepción, Concepción 4070386, VIII–Bio Bio Region, Chile
5
Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria
6
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade 11129, Serbia
7
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran
8
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
9
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
10
Institute for Research and Innovation in Health (i3S), University of Porto–Portugal, Porto 4200-135, Portugal
11
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy
12
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
13
Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 30 June 2018 / Revised: 12 July 2018 / Accepted: 14 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Bioactive Plant Compounds for Sustainable Health)
Abstract
In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed. View Full-TextKeywords:
peptic ulcer; Helicobacter pylori; gastric cancer; bioactive phytochemicals; herbal remedies; traditional healing systems
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Sharifi-Rad, M.; Fokou, P.V.T.; Sharopov, F.; Martorell, M.; Ademiluyi, A.O.; Rajkovic, J.; Salehi, B.; Martins, N.; Iriti, M.; Sharifi-Rad, J. Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion. Molecules 2018, 23, 1751.
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