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Molecules 2018, 23(7), 1629; https://doi.org/10.3390/molecules23071629

Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects

1
Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo Ó Higgins 3363, Casilla 40, Correo 33, Estación Central, 9170022 Santiago, Chile
2
Facultad de Ingeniería, Instituto de Ciencias Químicas Aplicadas, Polymers and Macromolecules Center, Universidad Autónoma de Chile, El Llano Subercaseaux 2801, San Miguel, 9170022 Santiago, Chile
3
Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, 9170022 Santiago, Chile
*
Author to whom correspondence should be addressed.
Received: 28 May 2018 / Revised: 20 June 2018 / Accepted: 30 June 2018 / Published: 4 July 2018
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications. View Full-Text
Keywords: silver antibacterial; Staphylococcus epidermidis; human ovarian cancer cell (A2780); murine fibroblast silver antibacterial; Staphylococcus epidermidis; human ovarian cancer cell (A2780); murine fibroblast
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Aldabaldetrecu, M.; Tamayo, L.; Alarcon, R.; Walter, M.; Salas-Huenuleo, E.; Kogan, M.J.; Guerrero, J.; Paez, M.; Azócar, M.I. Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects. Molecules 2018, 23, 1629.

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